Immune Support Peptides
Peptides that modulate the immune system, including thymic peptides, antimicrobial peptides, and immune regulators. Research areas include autoimmune conditions, infection resistance, and immune reconstitution.
Other Categories
Afamelanotide
Afamelanotide (Scenesse): FDA-approved MC1R agonist for erythropoietic protoporphyria. Subcutaneous implant increases pain-free sun exposure via melanogenesis.
Cortistatin
Cortistatin (CST-14): brain-specific neuropeptide that promotes slow-wave sleep, modulates inflammation, and shares structural homology with somatostatin. Preclinical research review.
Epitalon
Epitalon: Telomerase-activating anti-aging tetrapeptide. Covers telomere elongation, pineal gland modulation, Khavinson research, and dosing data.
FOXO4-DRI
FOXO4-DRI: Senolytic peptide targeting senescent cells. Covers FOXO4-p53 disruption, aging reversal research by Baar et al., dosing, and limitations.
Glepaglutide
Glepaglutide (ZP1848): long-acting GLP-2 analog for short bowel syndrome. Phase 3 data shows significant parenteral support reduction. Twice-weekly dosing.
Glutathione
Glutathione: The body's master antioxidant tripeptide. Covers redox cycling, detoxification, immune support, IV vs oral bioavailability, and dosing.
Icotrokinra
Icotrokinra (JNJ-2113): first-in-class oral peptide targeting the IL-23 receptor. Phase 3 ICONIC trials show 65% IGA 0/1 response. NDA submitted July 2025.
IO102-IO103
IO102-IO103 (Cylembio): dual IDO/PD-L1 peptide cancer vaccine. Phase 3 data shows 8.4-month PFS improvement in melanoma. FDA Breakthrough Therapy.
KPV
KPV (Lys-Pro-Val): alpha-MSH-derived anti-inflammatory tripeptide. Inhibits NF-kB without melanocortin receptors. IBD, gut inflammation, and skin research with dosing data.
Larazotide
Larazotide acetate: zonulin receptor antagonist for celiac disease. Phase 2b/3 results, tight junction regulation, and intestinal permeability reduction.
LL-37
LL-37: Human cathelicidin antimicrobial peptide guide. Covers membrane disruption, broad-spectrum antibacterial activity, wound healing, and immunity.
Motixafortide
Motixafortide (APHEXDA): FDA-approved CXCR4 antagonist peptide for stem cell mobilization in multiple myeloma. 92.5% success rate in GENESIS Phase 3 trial.
Pegcetacoplan
Pegcetacoplan (Empaveli/Syfovre): FDA-approved PEGylated cyclic peptide C3 complement inhibitor for PNH and geographic atrophy. Apellis Pharmaceuticals.
PNC-27
PNC-27: p53-derived anticancer peptide guide. Covers selective HDM-2 binding on cancer membranes, pore-forming cytotoxicity, and research limitations.
Rusfertide
Rusfertide (PTG-300): hepcidin mimetic peptide for polycythemia vera. Phase 3 VERIFY showed 77% response rate. FDA Breakthrough Therapy designation.
Selank
Selank: Tuftsin-derived anxiolytic nootropic peptide. Covers GABA modulation, anti-anxiety effects, cognitive enhancement, intranasal dosing, and safety.
Tat-Beclin-1
Tat-Beclin-1: cell-permeable autophagy-inducing peptide from beclin 1/HIV Tat. Preclinical antiviral, anticancer, and neuroprotective research applications.
TB500
TB-500: Thymosin beta-4 guide for tissue repair and healing. Covers actin regulation, wound healing, cardioprotective research, dosing, and side effects.
Thymalin
Thymalin: Thymic peptide bioregulator for immune restoration. Covers T-cell support, pineal-thymic axis aging research, Khavinson studies, and dosing.
Thymosin Alpha-1
Thymosin Alpha-1: Immunomodulator approved in 35+ countries. Covers T-cell and dendritic cell activation, hepatitis B trials, Zadaxin dosing, and safety.
Vilon
Vilon (Lys-Glu): synthetic dipeptide bioregulator with immunomodulatory and geroprotective effects. Preclinical research in lifespan extension and chromatin reactivation.
VIP
VIP: Vasoactive Intestinal Peptide guide. Covers vasodilation, gut motility, CIRS/mold illness research, circadian effects, and immune modulation.
Zilucoplan
Zilucoplan (Zilbrysq): FDA-approved macrocyclic peptide C5 complement inhibitor for generalized myasthenia gravis. Daily SC self-injection by UCB.
Head-to-Head Comparisons
Detailed comparisons between immune support peptides covering mechanisms, efficacy, side effects, and research evidence.
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Research review of anti-aging peptides organized by mechanism of action including senolytic peptides (FOXO4-DRI), telomere peptides (epitalon), mitochondrial peptides (SS-31, MOTS-c), tissue remodelers (GHK-Cu), and bioregulators (pinealon, thymalin). Evidence quality assessment for each approach.
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A comprehensive decision framework to help beginners identify the right peptide for their goals. Maps 10 health categories to specific peptide recommendations with evidence levels, administration routes, and regulatory context.
Research Tools
Use our interactive tools to explore immune support peptides further.