Brain & Neuroprotection Peptides
Peptides researched for their ability to protect brain and nerve cells from damage, degeneration, and ischemia. Includes compounds targeting oxidative stress, inflammation, and excitotoxicity in neural tissue.
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ARA-290
ARA-290 (Cibinetide): EPO-derived neuroprotective peptide. Covers innate repair receptor activation, sarcoidosis trials, dosing, and safety profile.
BPC-157
BPC-157 peptide comprehensive research guide. Covers mechanism of action (VEGF, nitric oxide, tendon healing), gut protection, musculoskeletal repair, oral vs injectable research, 2026 FDA reclassification status, safety profile, and clinical trial evidence for this gastric-derived healing peptide.
Brimapitide
Brimapitide (AM-111): cell-penetrating JNK inhibitor peptide for sudden hearing loss. Phase 3 HEALOS trial results and intratympanic delivery mechanism.
Cebranopadol
Cebranopadol (GRT-6005): first-in-class dual NOP/opioid receptor agonist for pain. Phase 3 ALLEVIATE trials positive. FDA Fast Track for chronic low back pain.
Cerebrolysin
Cerebrolysin: Brain-derived peptide for stroke and TBI recovery. Covers neurotrophic mechanisms, approvals in 40+ countries, dosing, and safety data.
Davunetide
Davunetide (NAP): ADNP-derived octapeptide microtubule stabilizer. Covers PSP phase 2/3 trial failure, intranasal delivery, and ADNP syndrome research.
Dermorphin
Dermorphin: Potent frog-derived opioid peptide with 40x morphine selectivity. Covers mu-opioid mechanism, analgesic research, and safety concerns.
DSIP
DSIP: Delta sleep-inducing nonapeptide guide. Covers EEG sleep effects, stress hormone modulation, opioid withdrawal research, dosing, and safety.
EPO
EPO: FDA-approved hormone for anemia and red blood cell production. Covers erythropoiesis, neuroprotective research, dosing, and doping concerns.
Humanin
Humanin: 24-amino acid mitochondrial-derived peptide with anti-apoptotic and neuroprotective effects. Research in Alzheimer's, aging, and metabolic disease.
Klotho Peptides
Comprehensive klotho peptide research guide covering KP1 and KP6 klotho-derived peptides for kidney fibrosis and diabetic kidney disease, alpha-klotho protein for cognitive enhancement and neuroprotection, FGF23 signaling, anti-aging mechanisms, and the latest clinical trial developments in 2026.
Nomlabofusp
Nomlabofusp (CTI-1601): TAT-frataxin fusion protein for Friedreich ataxia. Phase 2 complete, BLA planned Q2 2026. First disease-modifying FA therapy.
Risuteganib
Risuteganib (Luminate/ALG-1001): first-in-class integrin-regulating peptide for dry AMD. Phase 2a showed 48% of patients gained 8+ ETDRS letters vs 7% sham.
Semax
Semax peptide guide: not FDA approved, but used in Russia since 2011. Covers BDNF upregulation, stroke recovery data, intranasal dosing, and safety risks.
Ziconotide
Ziconotide (Prialt): FDA-approved intrathecal peptide from cone snail venom. Blocks N-type calcium channels for severe chronic pain refractory to other therapies.
Zilucoplan
Zilucoplan (Zilbrysq): FDA-approved macrocyclic peptide C5 complement inhibitor for generalized myasthenia gravis. Daily SC self-injection by UCB.
Head-to-Head Comparisons
Detailed comparisons between brain & neuroprotection peptides covering mechanisms, efficacy, side effects, and research evidence.
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Research Tools
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