Cognitive Enhancement Peptides
Neuropeptides and nootropic compounds researched for cognitive enhancement, memory support, and neuroprotection. Includes peptides targeting BDNF, NMDA receptors, and other pathways involved in brain health.
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Cerebrolysin
Cerebrolysin: Brain-derived peptide for stroke and TBI recovery. Covers neurotrophic mechanisms, approvals in 40+ countries, dosing, and safety data.
Davunetide
Davunetide (NAP): ADNP-derived octapeptide microtubule stabilizer. Covers PSP phase 2/3 trial failure, intranasal delivery, and ADNP syndrome research.
Dihexa
Dihexa (PNB-0408): angiotensin IV-derived peptide that potentiates HGF/c-Met signaling. Covers preclinical cognitive enhancement research, oral bioavailability, and safety considerations.
NAD+
NAD+ (Nicotinamide Adenine Dinucleotide): Essential coenzyme for cellular energy, DNA repair, and anti-aging research. Covers sirtuins, PARPs, CD38, NAD+ decline with aging, precursor strategies, and clinical evidence.
Nemifitide
Nemifitide (INN-00835): pentapeptide MIF-1 analog with rapid-onset antidepressant effects (5-7 days). Phase 3 clinical trials for major depressive disorder.
PE-22-28
PE-22-28: synthetic spadin analog TREK-1 potassium channel blocker. Preclinical antidepressant effects and hippocampal neurogenesis within 4 days of treatment.
Pinealon
Pinealon (EDR): Bioregulatory neuroprotective tripeptide. Covers epigenetic gene regulation, cognitive enhancement research, and Khavinson science.
Rapastinel
Rapastinel (GLYX-13): NMDA receptor glycine-site partial agonist. Covers phase 2 antidepressant results, failed phase 3 trials, and rapid-acting mechanism.
Selank
Selank: Tuftsin-derived anxiolytic nootropic peptide. Covers GABA modulation, anti-anxiety effects, cognitive enhancement, intranasal dosing, and safety.
Semax
Semax peptide guide: not FDA approved, but used in Russia since 2011. Covers BDNF upregulation, stroke recovery data, intranasal dosing, and safety risks.
Head-to-Head Comparisons
Detailed comparisons between cognitive enhancement peptides covering mechanisms, efficacy, side effects, and research evidence.
Related Articles
Peptide Therapy for Brain Health: Neuroprotection, Cognition, and Recovery
Comprehensive guide to peptides for brain health covering neurotrophic factors, neuroprotective agents, anxiolytics, and experimental cognitive enhancers. Includes cerebrolysin, semax, selank, BPC-157, dihexa, pinealon, SS-31, and rapastinel.
guideNootropic Peptide Stacks: What Research Says About Combining Cognitive Peptides
Evidence-based review of nootropic peptide stacking, including Semax+Selank combinations, BDNF upregulation stacks, and neuroprotective synergies.
guideBest Nootropic Peptides for Cognitive Enhancement: 2026 Guide
Comprehensive 2026 guide to 8 nootropic peptides for cognitive enhancement — dihexa, semax, selank, cerebrolysin, PE-22-28, davunetide, pinealon, and humanin — grouped by mechanism including BDNF upregulation, synaptogenesis, neuroprotection, and anxiolytic pathways.
guideBest Nootropic Peptides for Cognitive Enhancement
Top nootropic peptides for cognitive enhancement — selank, semax, cerebrolysin, pinealon, and DSIP — with evidence levels and mechanisms.
research-reviewPeptides for Brain Injury and Neuroprotection: TBI, Stroke, and Neurodegeneration Research
Research review of neuroprotective peptides for TBI, stroke, and neurodegeneration, including Semax, Davunetide, BPC-157, and Dihexa.
research-reviewAnti-Aging Peptides by Mechanism: Senolytics, Telomeres, Mitochondria, and Hormones
Research review of anti-aging peptides organized by mechanism of action including senolytic peptides (FOXO4-DRI), telomere peptides (epitalon), mitochondrial peptides (SS-31, MOTS-c), tissue remodelers (GHK-Cu), and bioregulators (pinealon, thymalin). Evidence quality assessment for each approach.
Research Tools
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