Neuropeptides Peptides
Signaling peptides active in the nervous system that modulate neurotransmission, pain perception, and neuroendocrine function. Includes substance P analogs, neuropeptide Y, and related compounds.
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Dihexa
Dihexa (PNB-0408): angiotensin IV-derived peptide that potentiates HGF/c-Met signaling. Covers preclinical cognitive enhancement research, oral bioavailability, and safety considerations.
Kisspeptin
Kisspeptin: Master HPG axis regulator for fertility research. Covers GnRH neuron activation, Phase 2 trial data, IVF applications, and safety.
Nemifitide
Nemifitide (INN-00835): pentapeptide MIF-1 analog with rapid-onset antidepressant effects (5-7 days). Phase 3 clinical trials for major depressive disorder.
Neuropeptide Y
Neuropeptide Y (NPY): 36-amino acid endogenous peptide regulating stress resilience, appetite, and anxiety. Intranasal delivery studied for depression and PTSD.
Oveporexton
Oveporexton (TAK-861): first-in-class oral OX2R-selective agonist for narcolepsy type 1. Phase 3 FirstLight/RadiantLight trial results, mechanism, dosing, and NDA filing status.
PE-22-28
PE-22-28: synthetic spadin analog TREK-1 potassium channel blocker. Preclinical antidepressant effects and hippocampal neurogenesis within 4 days of treatment.
Rapastinel
Rapastinel (GLYX-13): NMDA receptor glycine-site partial agonist. Covers phase 2 antidepressant results, failed phase 3 trials, and rapid-acting mechanism.
VIP
VIP: Vasoactive Intestinal Peptide guide. Covers vasodilation, gut motility, CIRS/mold illness research, circadian effects, and immune modulation.
Head-to-Head Comparisons
Detailed comparisons between neuropeptides peptides covering mechanisms, efficacy, side effects, and research evidence.
Related Articles
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Evidence-based review of nootropic peptide stacking, including Semax+Selank combinations, BDNF upregulation stacks, and neuroprotective synergies.
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Research review of neuroprotective peptides for TBI, stroke, and neurodegeneration, including Semax, Davunetide, BPC-157, and Dihexa.
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Comprehensive 2026 guide to 8 nootropic peptides for cognitive enhancement — dihexa, semax, selank, cerebrolysin, PE-22-28, davunetide, pinealon, and humanin — grouped by mechanism including BDNF upregulation, synaptogenesis, neuroprotection, and anxiolytic pathways.
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Research guide covering peptides studied for menopause symptoms including hot flashes, bone loss, cognitive changes, skin aging, sleep disruption, and hormonal regulation.
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Peptides for sexual health — PT-141, kisspeptin, Melanotan-2, and oxytocin — covering mechanisms, clinical evidence, and safety data.
Research Tools
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