Skin & Hair Peptides
Peptides studied for skin repair, rejuvenation, and protection. Includes melanocyte-stimulating hormones, collagen-boosting peptides, and compounds researched for wound healing and dermatological conditions.
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Afamelanotide
Afamelanotide (Scenesse): FDA-approved MC1R agonist for erythropoietic protoporphyria. Subcutaneous implant increases pain-free sun exposure via melanogenesis.
Argireline
Argireline (acetyl hexapeptide-8): topical SNARE complex inhibitor for dynamic wrinkle reduction. Up to 30% wrinkle depth improvement as a non-invasive Botox alternative.
GHK-Cu
GHK-Cu: Copper tripeptide for skin healing and anti-aging. Covers collagen stimulation, wound repair, hair growth, and topical vs injectable use.
Icotrokinra
Icotrokinra (JNJ-2113): first-in-class oral peptide targeting the IL-23 receptor. Phase 3 ICONIC trials show 65% IGA 0/1 response. NDA submitted July 2025.
Matrixyl
Matrixyl (palmitoyl pentapeptide-4): collagen-stimulating cosmeceutical peptide. Clinical studies show wrinkle reduction via matrikine signaling in fibroblasts.
Melanotan-1
Melanotan-1 (Afamelanotide): Approved alpha-MSH analog. Covers melanocortin mechanism, Scenesse for EPP, photoprotective tanning, and safety data.
Melanotan-2
Melanotan-2: Cyclic melanocortin peptide for tanning and sexual function. Covers MC1R/MC4R activation, dosing protocols, side effects, and regulation.
OS-01 (Peptide 14)
OS-01 (Peptide 14) is a senotherapeutic decapeptide targeting cellular senescence via PP2A modulation. Published RCT data shows skin barrier and aging improvements.
Pegcetacoplan
Pegcetacoplan (Empaveli/Syfovre): FDA-approved PEGylated cyclic peptide C3 complement inhibitor for PNH and geographic atrophy. Apellis Pharmaceuticals.
PP405
PP405: first-in-class topical MPC inhibitor for hair loss by Pelage Pharma. Reactivates dormant follicle stem cells. Phase 2a showed 31% responder rate.
PT-141
PT-141 (Bremelanotide): FDA-approved for hypoactive sexual desire. Covers MC4R mechanism, Vyleesi trial data, dosing, and side effects.
SNAP-8
SNAP-8: Botox-like cosmeceutical peptide for wrinkle reduction. Covers SNARE complex inhibition, topical formulation research, and Argireline comparison.
Head-to-Head Comparisons
Detailed comparisons between skin & hair peptides covering mechanisms, efficacy, side effects, and research evidence.
Related Articles
Anti-Wrinkle Peptides: SNAP-8, Argireline, Matrixyl, and Leuphasyl Compared
Evidence-based guide to cosmeceutical anti-wrinkle peptides including SNAP-8, Argireline, Matrixyl, and GHK-Cu — mechanisms, clinical data, and formulation.
guideMost Popular Therapeutic Peptides in 2026: 15 Ranked by Research Interest
The 15 most popular therapeutic peptides in 2026, ranked by clinical trial activity, search interest, and research community adoption. From semaglutide to BPC-157.
guideBest Peptides for Menopause Symptoms: 2026 Research Guide
Research guide covering peptides studied for menopause symptoms including hot flashes, bone loss, cognitive changes, skin aging, sleep disruption, and hormonal regulation.
research-reviewAnti-Aging Peptides by Mechanism: Senolytics, Telomeres, Mitochondria, and Hormones
Research review of anti-aging peptides organized by mechanism of action including senolytic peptides (FOXO4-DRI), telomere peptides (epitalon), mitochondrial peptides (SS-31, MOTS-c), tissue remodelers (GHK-Cu), and bioregulators (pinealon, thymalin). Evidence quality assessment for each approach.
guideHow to Choose Your First Peptide: A Decision Framework by Goal
A comprehensive decision framework to help beginners identify the right peptide for their goals. Maps 10 health categories to specific peptide recommendations with evidence levels, administration routes, and regulatory context.
research-reviewThe Science of Peptide Stacking: Synergies, Risks, and Evidence
A research-focused examination of peptide stacking science, covering synergistic mechanisms, evidence-based stacks, theoretical combinations, contraindicated pairings, and the gap between community protocols and published research.
Research Tools
Use our interactive tools to explore skin & hair peptides further.