Skin & Hair Peptides
Peptides studied for skin repair, rejuvenation, and protection. Includes melanocyte-stimulating hormones, collagen-boosting peptides, and compounds researched for wound healing and dermatological conditions.
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Afamelanotide
Afamelanotide (Scenesse): FDA-approved MC1R agonist for erythropoietic protoporphyria. Subcutaneous implant increases pain-free sun exposure via melanogenesis.
Argireline
Argireline (acetyl hexapeptide-8): topical SNARE complex inhibitor for dynamic wrinkle reduction. Up to 30% wrinkle depth improvement as a non-invasive Botox alternative.
GHK-Cu
GHK-Cu: Copper tripeptide for skin healing and anti-aging. Covers collagen stimulation, wound repair, hair growth, and topical vs injectable use.
Icotrokinra
Icotrokinra (JNJ-2113): first-in-class oral peptide targeting the IL-23 receptor. Phase 3 ICONIC trials show 65% IGA 0/1 response. NDA submitted July 2025.
Matrixyl
Matrixyl (palmitoyl pentapeptide-4): collagen-stimulating cosmeceutical peptide. Clinical studies show wrinkle reduction via matrikine signaling in fibroblasts.
Melanotan-1
Melanotan-1 (Afamelanotide): Approved alpha-MSH analog. Covers melanocortin mechanism, Scenesse for EPP, photoprotective tanning, and safety data.
Melanotan-2
Melanotan-2: Cyclic melanocortin peptide for tanning and sexual function. Covers MC1R/MC4R activation, dosing protocols, side effects, and regulation.
OS-01 (Peptide 14)
OS-01 (Peptide 14) is a senotherapeutic decapeptide targeting cellular senescence via PP2A modulation. Published RCT data shows skin barrier and aging improvements.
Pegcetacoplan
Pegcetacoplan (Empaveli/Syfovre): FDA-approved PEGylated cyclic peptide C3 complement inhibitor for PNH and geographic atrophy. Apellis Pharmaceuticals.
PP405
PP405: first-in-class topical MPC inhibitor for hair loss by Pelage Pharma. Reactivates dormant follicle stem cells. Phase 2a showed 31% responder rate.
PT-141
PT-141 (Bremelanotide): FDA-approved for hypoactive sexual desire. Covers MC4R mechanism, Vyleesi trial data, dosing, and side effects.
SNAP-8
SNAP-8: Botox-like cosmeceutical peptide for wrinkle reduction. Covers SNARE complex inhibition, topical formulation research, and Argireline comparison.
Head-to-Head Comparisons
Detailed comparisons between skin & hair peptides covering mechanisms, efficacy, side effects, and research evidence.
Related Articles
Melanotan Tanning Peptides: Risks and Research Evidence
Melanotan-1 and Melanotan-2 tanning peptide review — how they work, documented risks including mole changes, side effects, and legal status.
guideBest Peptides for Hair, Skin & Nails: Evidence-Based Guide (2026)
Which peptides actually improve hair growth, skin quality, and nail strength? Evidence-based review of GHK-Cu, copper peptides, Matrixyl, BPC-157, and popular peptide blends.
guideAnti-Wrinkle Peptides: SNAP-8, Argireline, Matrixyl, and Leuphasyl Compared
Evidence-based guide to cosmeceutical anti-wrinkle peptides including SNAP-8, Argireline, Matrixyl, and GHK-Cu — mechanisms, clinical data, and formulation.
guideFDA Peptide Categories Explained: Category 1 vs Category 2 (2026)
Understand the FDA peptide classification system. Learn the difference between Category 1, Category 2, and Category 3 peptides and what the 2024-2026 regulatory changes mean for researchers.
guideBest Peptides for Tendon Repair and Recovery: Research Guide
An evidence-based review of peptides with the strongest preclinical and clinical data for tendon repair, including BPC-157, TB-500, GHK-Cu, and IGF-1 LR3 — covering mechanisms, research findings, and protocol considerations.
guidePeptide Stacking Guide 2026: Best Combinations by Goal
The definitive 2026 guide to peptide stacking organized by goal. Fat loss, muscle growth, healing, anti-aging, and cognitive stacks with evidence levels, dosing timing, and safety considerations.
Research Tools
Use our interactive tools to explore skin & hair peptides further.