Skin & Hair Peptides
Peptides studied for skin repair, rejuvenation, and protection. Includes melanocyte-stimulating hormones, collagen-boosting peptides, and compounds researched for wound healing and dermatological conditions.
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Afamelanotide
Afamelanotide (Scenesse): FDA-approved MC1R agonist for erythropoietic protoporphyria. Subcutaneous implant increases pain-free sun exposure via melanogenesis.
Argireline
Argireline (acetyl hexapeptide-8): topical SNARE complex inhibitor for dynamic wrinkle reduction. Up to 30% wrinkle depth improvement as a non-invasive Botox alternative.
GHK-Cu
GHK-Cu: Copper tripeptide for skin healing and anti-aging. Covers collagen stimulation, wound repair, hair growth, and topical vs injectable use.
Icotrokinra
Icotrokinra (JNJ-2113): first-in-class oral peptide targeting the IL-23 receptor. Phase 3 ICONIC trials show 65% IGA 0/1 response. NDA submitted July 2025.
Matrixyl
Matrixyl (palmitoyl pentapeptide-4): collagen-stimulating cosmeceutical peptide. Clinical studies show wrinkle reduction via matrikine signaling in fibroblasts.
Melanotan-1
Melanotan-1 (Afamelanotide): Approved alpha-MSH analog. Covers melanocortin mechanism, Scenesse for EPP, photoprotective tanning, and safety data.
Melanotan-2
Melanotan-2: Cyclic melanocortin peptide for tanning and sexual function. Covers MC1R/MC4R activation, dosing protocols, side effects, and regulation.
OS-01 (Peptide 14)
OS-01 (Peptide 14) is a senotherapeutic decapeptide targeting cellular senescence via PP2A modulation. Published RCT data shows skin barrier and aging improvements.
Pegcetacoplan
Pegcetacoplan (Empaveli/Syfovre): FDA-approved PEGylated cyclic peptide C3 complement inhibitor for PNH and geographic atrophy. Apellis Pharmaceuticals.
PP405
PP405: first-in-class topical MPC inhibitor for hair loss by Pelage Pharma. Reactivates dormant follicle stem cells. Phase 2a showed 31% responder rate.
PT-141
PT-141 (Bremelanotide): FDA-approved for hypoactive sexual desire. Covers MC4R mechanism, Vyleesi trial data, dosing, and side effects.
SNAP-8
SNAP-8: Botox-like cosmeceutical peptide for wrinkle reduction. Covers SNARE complex inhibition, topical formulation research, and Argireline comparison.
Head-to-Head Comparisons
Detailed comparisons between skin & hair peptides covering mechanisms, efficacy, side effects, and research evidence.
Related Articles
Anti-Wrinkle Peptides: SNAP-8, Argireline, Matrixyl, and Leuphasyl Compared
Evidence-based guide to cosmeceutical anti-wrinkle peptides including SNAP-8, Argireline, Matrixyl, and GHK-Cu — mechanisms, clinical data, and formulation.
guideBest Peptides for Hair, Skin & Nails: Evidence-Based Guide (2026)
Which peptides actually improve hair growth, skin quality, and nail strength? Evidence-based review of GHK-Cu, copper peptides, Matrixyl, BPC-157, and popular peptide blends.
guideBest Peptides for Tendon Repair and Recovery: Research Guide
An evidence-based review of peptides with the strongest preclinical and clinical data for tendon repair, including BPC-157, TB-500, GHK-Cu, and IGF-1 LR3 — covering mechanisms, research findings, and protocol considerations.
guidePeptide Stacking Guide 2026: Best Combinations by Goal
The definitive 2026 guide to peptide stacking organized by goal. Fat loss, muscle growth, healing, anti-aging, and cognitive stacks with evidence levels, dosing timing, and safety considerations.
guideMost Popular Therapeutic Peptides in 2026: 15 Ranked by Research Interest
The 15 most popular therapeutic peptides in 2026, ranked by clinical trial activity, search interest, and research community adoption. From semaglutide to BPC-157.
guideBest Peptides for Menopause Symptoms: 2026 Research Guide
Research guide covering peptides studied for menopause symptoms including hot flashes, bone loss, cognitive changes, skin aging, sleep disruption, and hormonal regulation.
Research Tools
Use our interactive tools to explore skin & hair peptides further.