Semaglutide Dosing Calculator

Dose

0.25-2.5 mg

Frequency

Once weekly

Duration

Ongoing

Route

Subcutaneous

Uses compounded vials (typically 5 mg/2 mL or 10 mg/2 mL concentration); requires careful syringe measurement; community reports dosing errors due to concentration confusion

Dose

0.5-1.0 mg

Frequency

Once weekly

Duration

Ongoing

Route

Subcutaneous

Some users stabilize at lower maintenance doses to minimize GI side effects while maintaining weight loss; common among those who find higher doses intolerable

Dose

0.125-0.25 mg

Frequency

2 times weekly (splitting weekly dose)

Duration

Ongoing

Route

Subcutaneous

Some community members split their weekly dose into two smaller injections to reduce peak-related side effects like nausea; not studied in clinical trials

Dose

Start 0.25 mg weekly SC for 4 weeks, then increase to 0.5 mg weekly. May increase to 1 mg weekly after at least 4 weeks, then to 2 mg weekly after at least 4 weeks at 1 mg if additional glycemic control needed.

Frequency

Once weekly subcutaneous injection

Duration

Ongoing; long-term maintenance therapy

0.25 mg is the starting dose for GI tolerability, not a therapeutic dose. Minimum therapeutic dose is 0.5 mg. The 2 mg dose provides additional HbA1c reduction beyond 1 mg.

Dose

Start 0.25 mg weekly SC for 4 weeks, then escalate: 0.5 mg (weeks 5-8), 1.0 mg (weeks 9-12), 1.7 mg (weeks 13-16), 2.4 mg (week 17 onward).

Frequency

Once weekly subcutaneous injection

Duration

Ongoing; long-term weight management

Target maintenance dose is 2.4 mg weekly. If patient does not tolerate dose increase, delay escalation by 4 weeks. If 2.4 mg is not tolerated, 1.7 mg maintenance may be considered.

How much bacteriostatic water should I add to a 10 mg vial of Semaglutide?

The community standard is 2 mL of bacteriostatic water for a 10 mg Semaglutide vial. That gives a concentration of 5.00 mg/mL, so a 250 mcg dose is 5 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 10.00 mg/mL and halves the draw to 2.5 units. Less water = smaller injection volume but harder to measure precisely.

How many syringe units is a 250 mcg dose of Semaglutide?

On a standard U-100 insulin syringe, a 250 mcg dose of Semaglutide is 5 units when the 10 mg vial is reconstituted with 2 mL of bacteriostatic water (5.00 mg/mL). If you use 1 mL of bac water instead, draw 2.5 units (10.00 mg/mL).

What is the standard Semaglutide dose?

Community-reported protocols for Semaglutide typically use 0.25 mg–2.4 mg once weekly via Subcutaneous. 250 mcg is a common starting dose. Mirrors FDA-approved Wegovy titration: 0.25 mg x4 weeks, 0.5 mg x4 weeks, 1.0 mg x4 weeks, 1.7 mg x4 weeks, then 2.4 mg maintenance

How long does a vial of Semaglutide last at 250 mcg once weekly?

A 10 mg vial of Semaglutide contains roughly 40 doses at 250 mcg per injection. At once weekly dosing, that is approximately 280 days (about 40 weeks) of supply per vial. Reconstituted Semaglutide should generally be used within 28 days when refrigerated.

Where do you inject Semaglutide?

Semaglutide is typically injected subcutaneous. Common sites reported in the literature and by users include: Abdomen (at least 2 inches from navel), Front of thigh (middle third), Upper arm (back, upper outer area -- may require assistance). Rotate sites with each injection to reduce localized irritation.

Can I use sterile water instead of bacteriostatic water for Semaglutide?

Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Semaglutide because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.