Ribupatide Dosing Calculator

Dose

10 mg, 25 mg, or 50 mg once daily oral tablet.

Frequency

Once daily oral

Duration

26 weeks (Phase 2 trial)

Mean weight loss of 6.9% (10 mg), 12.1% (25 mg), and 12.1% (50 mg) versus 2.3% placebo at 26 weeks. Up to 38.6% of participants on oral ribupatide achieved at least 15% weight loss.

Dose

Dose escalation with HRS9531 once weekly subcutaneous injection.

Frequency

Once weekly subcutaneous injection

Duration

Phase 3 ongoing

Hengrui has completed Phase 3 obesity trials in China and reported additional data showing significant weight loss results.

How much bacteriostatic water should I add to a 15 mg vial of Ribupatide?

The community standard is 2 mL of bacteriostatic water for a 15 mg Ribupatide vial. That gives a concentration of 7.50 mg/mL, so a 8 mg dose is 106.7 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 15.00 mg/mL and halves the draw to 53.3 units. Less water = smaller injection volume but harder to measure precisely.

How many syringe units is a 8 mg dose of Ribupatide?

On a standard U-100 insulin syringe, a 8 mg dose of Ribupatide is 106.7 units when the 15 mg vial is reconstituted with 2 mL of bacteriostatic water (7.50 mg/mL). If you use 1 mL of bac water instead, draw 53.3 units (15.00 mg/mL).

What is the standard Ribupatide dose?

Clinical protocols for Ribupatide typically use 8 mg–36 mg once weekly via subcutaneous injection. 8 mg is a common starting dose. The 8 mg dose achieved 22.8% mean weight loss (21.1% placebo-adjusted) at 36 weeks. 59% of participants achieved 20% or more weight loss. No plateau was observed at end of treatment.

How long does a vial of Ribupatide last at 8 mg once weekly?

A 15 mg vial of Ribupatide contains roughly 1 doses at 8 mg per injection. At once weekly dosing, that is approximately 7 days (about 1 weeks) of supply per vial. Reconstituted Ribupatide should generally be used within 28 days when refrigerated.

Where do you inject Ribupatide?

Ribupatide is typically injected subcutaneously. Common sites reported in the literature and by users include: Abdomen, Thigh, Upper arm. Rotate sites with each injection to reduce localized irritation.

Can I use sterile water instead of bacteriostatic water for Ribupatide?

Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Ribupatide because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.