Retatrutide Dosing Calculator

Dose

0.5-4 mg

Frequency

Once weekly

Duration

12-24 weeks

Route

Subcutaneous

Some community members start at sub-clinical doses (0.5 mg) and escalate more slowly than clinical protocols to assess individual tolerance

Dose

4-8 mg

Frequency

Once weekly

Duration

Ongoing

Route

Subcutaneous

Users report significant weight loss and appetite suppression at 4-8 mg without needing to reach 12 mg; lower doses may reduce GI and other side effects

Dose

Starting dose 0.5 mg weekly, escalated over 12-24 weeks to target doses (1 mg, 4 mg, 8 mg, or 12 mg)

Frequency

Once weekly subcutaneous injection

Duration

48-week treatment period

Investigational protocol only; not for clinical use outside trials

Dose

Starting dose 0.5 mg weekly, escalated to target doses up to 12 mg

Frequency

Once weekly subcutaneous injection

Duration

36-week treatment period

Investigational protocol in patients with type 2 diabetes; background metformin permitted

How much bacteriostatic water should I add to a 20 mg vial of Retatrutide?

The community standard is 2 mL of bacteriostatic water for a 20 mg Retatrutide vial. That gives a concentration of 10.00 mg/mL, so a 1 mg dose is 10 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 20.00 mg/mL and halves the draw to 5 units. Less water = smaller injection volume but harder to measure precisely.

How many syringe units is a 1 mg dose of Retatrutide?

On a standard U-100 insulin syringe, a 1 mg dose of Retatrutide is 10 units when the 20 mg vial is reconstituted with 2 mL of bacteriostatic water (10.00 mg/mL). If you use 1 mL of bac water instead, draw 5 units (20.00 mg/mL).

What is the standard Retatrutide dose?

Community-reported protocols for Retatrutide typically use 1 mg–12 mg once weekly via Subcutaneous. 1 mg is a common starting dose. Based on Phase 2 trial schedule: 1 mg x4 weeks, 2 mg x4 weeks, 4 mg x4 weeks, escalating up to 8 or 12 mg; community users attempt to replicate clinical dosing

How long does a vial of Retatrutide last at 1 mg once weekly?

A 20 mg vial of Retatrutide contains roughly 20 doses at 1 mg per injection. At once weekly dosing, that is approximately 140 days (about 20 weeks) of supply per vial. Reconstituted Retatrutide should generally be used within 28 days when refrigerated.

Where do you inject Retatrutide?

Retatrutide is typically injected subcutaneous. Common sites reported in the literature and by users include: Subcutaneous (abdomen), Subcutaneous (thigh). Rotate sites with each injection to reduce localized irritation.

Can I use sterile water instead of bacteriostatic water for Retatrutide?

Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Retatrutide because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.