Mazdutide Dosing Calculator
Mazdutide: Dual GLP-1/glucagon agonist approved in China for obesity.
Pre-filled with the most-reported community reconstitution protocol for Mazdutide. See how 1 mL and 2 mL of bacteriostatic water change concentration and syringe-draw volume, then adjust the calculator below for your own vial.
Quick answer · Community-reported standard
A 10 mg vial of Mazdutide reconstituted with 2 mL of bacteriostatic water yields a concentration of 5.00 mg/mL. At that concentration, a 3 mg dose of Mazdutide equals 60 units on a U-100 insulin syringe (0.600 mL). Mazdutide is typically administered once weekly via subcutaneous.
Mazdutide reconstitution: 1 mL vs 2 mL bac water
Bacteriostatic water volume is flexible. Less water means higher concentration and smaller injection volumes; more water means lower concentration and easier dose precision. Both options below are valid for a 10 mg vial.
| BAC water added | Concentration | Volume per 3 mg dose | Draw on U-100 syringe (units) |
|---|---|---|---|
| 1 mL | 10.00 mg/mL | 0.300 mL | 30 units |
| 2 mL | 5.00 mg/mL | 0.600 mL | 60 units |
Calculate your Mazdutide dose
Alternative Mazdutide protocols
Beyond the default above, Mazdutide is also reported in the following protocols. Use these as starting points and recalculate with the tool above.
Obesity/weight management (approved indication, China)
Clinical- Dose
- 4 mg, 6 mg, or 9 mg SC
- Frequency
- Once weekly
- Duration
- Ongoing (chronic treatment)
Gradual dose escalation from starting dose. Phase III GLORY trials demonstrated 10-20% weight loss at 48-60 weeks depending on dose. 9 mg dose achieved up to 20.1% weight loss.
Type 2 diabetes (clinical trial)
Clinical- Dose
- 3 mg, 4.5 mg, or 6 mg SC
- Frequency
- Once weekly
- Duration
- 24 weeks (Phase II trial duration)
Phase II trial showed HbA1c reduction of -1.57% (4 mg) and -2.15% (6 mg) vs -0.14% placebo at week 24. Dose-dependent glycemic improvement.
Phase 1b obesity dose-finding
Clinical- Dose
- 9 mg and 10 mg SC
- Frequency
- Once weekly
- Duration
- 12 weeks
Multiple-ascending-dose study. Mean weight loss of -11.7% (9 mg) vs -1.8% (placebo) at 12 weeks. Established tolerability of higher doses.
Mazdutide reconstitution & storage
Mazdutide is provided as a ready-to-use prefilled injection pen or solution. No reconstitution is required for the commercial formulation. For research formulations, reconstitute lyophilized powder with sterile water per manufacturer instructions.
Store prefilled pens at 2-8C (refrigerator). Protect from light. Do not freeze. In-use pens may be stored at room temperature (below 30C) for up to 21 days. Discard after 21 days at room temperature or after expiration date.
Mazdutide dosing FAQ
How much bacteriostatic water should I add to a 10 mg vial of Mazdutide?
The community standard is 2 mL of bacteriostatic water for a 10 mg Mazdutide vial. That gives a concentration of 5.00 mg/mL, so a 3 mg dose is 60 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 10.00 mg/mL and halves the draw to 30 units. Less water = smaller injection volume but harder to measure precisely.
How many syringe units is a 3 mg dose of Mazdutide?
On a standard U-100 insulin syringe, a 3 mg dose of Mazdutide is 60 units when the 10 mg vial is reconstituted with 2 mL of bacteriostatic water (5.00 mg/mL). If you use 1 mL of bac water instead, draw 30 units (10.00 mg/mL).
What is the standard Mazdutide dose?
Community-reported protocols for Mazdutide typically use 3 mgâ9 mg once weekly via Subcutaneous. 3 mg is a common starting dose. Based on Phase 3 trial doses (3, 4.5, 6, 9 mg weekly); mazdutide is approved in China but not in the US or EU; community access primarily through Chinese research suppliers
How long does a vial of Mazdutide last at 3 mg once weekly?
A 10 mg vial of Mazdutide contains roughly 3 doses at 3 mg per injection. At once weekly dosing, that is approximately 21 days (about 3 weeks) of supply per vial. Reconstituted Mazdutide should generally be used within 28 days when refrigerated.
Where do you inject Mazdutide?
Mazdutide is typically injected subcutaneous. Common sites reported in the literature and by users include: Abdomen (subcutaneous, preferred site), Thigh (subcutaneous), Upper arm (subcutaneous). Rotate sites with each injection to reduce localized irritation.
Can I use sterile water instead of bacteriostatic water for Mazdutide?
Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Mazdutide because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.
More on Mazdutide
Mazdutide overview
Mechanism of action, primary uses, and research summary
Mazdutide dosing protocols
Full clinical and research-based dosing reference
Mazdutide community protocols
Real-world usage patterns from peptide communities
Mazdutide side effects
Reported adverse effects and safety considerations
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Medical Disclaimer
This website is for educational and informational purposes only. The information provided is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare professional before using any peptide or supplement.