PT-141 Dosing Calculator
PT-141 (Bremelanotide): FDA-approved for hypoactive sexual desire.
Pre-filled with the most-reported community reconstitution protocol for PT-141. See how 1 mL and 2 mL of bacteriostatic water change concentration and syringe-draw volume, then adjust the calculator below for your own vial.
Quick answer · Community-reported standard
A 5 mg vial of PT-141 reconstituted with 2 mL of bacteriostatic water yields a concentration of 2.50 mg/mL. At that concentration, a 1.75 mg dose of PT-141 equals 70 units on a U-100 insulin syringe (0.700 mL). PT-141 is typically administered as needed via subcutaneous.
PT-141 reconstitution: 1 mL vs 2 mL bac water
Bacteriostatic water volume is flexible. Less water means higher concentration and smaller injection volumes; more water means lower concentration and easier dose precision. Both options below are valid for a 5 mg vial.
| BAC water added | Concentration | Volume per 1.75 mg dose | Draw on U-100 syringe (units) |
|---|---|---|---|
| 1 mL | 5.00 mg/mL | 0.350 mL | 35 units |
| 2 mL | 2.50 mg/mL | 0.700 mL | 70 units |
Calculate your PT-141 dose
Alternative PT-141 protocols
Beyond the default above, PT-141 is also reported in the following protocols. Use these as starting points and recalculate with the tool above.
Low-Dose Protocol
Community- Dose
- 0.5-1.0 mg
- Frequency
- As needed (60 minutes before activity)
- Duration
- On-demand
- Route
- Subcutaneous
Community-derived lower dose to reduce nausea; many users find 0.5-1.0 mg effective with fewer side effects
Male Erectile Support Protocol
Community- Dose
- 1.0-2.0 mg
- Frequency
- As needed (1-2 hours before activity)
- Duration
- On-demand
- Route
- Subcutaneous
Off-label male use; often combined with PDE5 inhibitors; some users require higher doses
Nasal Spray Protocol
Community- Dose
- 1.0-2.0 mg
- Frequency
- As needed
- Duration
- On-demand
- Route
- Intranasal
Some compounding pharmacies offer nasal spray formulation; reported faster onset but variable absorption
HSDD in premenopausal women (FDA-approved)
Clinical- Dose
- 1.75 mg
- Frequency
- As needed (PRN), at least 45 minutes before anticipated sexual activity
- Duration
- Ongoing as needed
FDA-approved dose administered via single-dose prefilled auto-injector. No more than one dose every 24 hours. No more than 8 doses per month. Self-administered subcutaneously in the abdomen or thigh.
Male erectile dysfunction research
Clinical- Dose
- 1.75 mg
- Frequency
- As needed (investigational)
- Duration
- Per clinical protocol
The same 1.75 mg dose has been used in Phase 2 male ED studies. Not FDA-approved for this indication. Combination with PDE5 inhibitors under investigation.
PT-141 reconstitution & storage
The FDA-approved Vyleesi product is supplied as a ready-to-use prefilled single-dose auto-injector and does not require reconstitution. For research-grade lyophilized PT-141, reconstitute with bacteriostatic water. For a 10 mg vial, add 5 mL bacteriostatic water for a concentration of 2 mg/mL (2000 mcg/mL). A 1.75 mg dose equals 0.875 mL. Gently swirl to dissolve, do not shake.
Vyleesi auto-injectors should be stored at 20-25 degrees Celsius (68-77 degrees Fahrenheit). Excursions permitted to 15-30 degrees Celsius. Protect from light. Do not freeze. For research-grade lyophilized PT-141, store powder at -20 degrees Celsius. Reconstituted solutions should be refrigerated at 2-8 degrees Celsius and used within 30 days.
PT-141 dosing FAQ
How much bacteriostatic water should I add to a 5 mg vial of PT-141?
The community standard is 2 mL of bacteriostatic water for a 5 mg PT-141 vial. That gives a concentration of 2.50 mg/mL, so a 1.75 mg dose is 70 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 5.00 mg/mL and halves the draw to 35 units. Less water = smaller injection volume but harder to measure precisely.
How many syringe units is a 1.75 mg dose of PT-141?
On a standard U-100 insulin syringe, a 1.75 mg dose of PT-141 is 70 units when the 5 mg vial is reconstituted with 2 mL of bacteriostatic water (2.50 mg/mL). If you use 1 mL of bac water instead, draw 35 units (5.00 mg/mL).
What is the standard PT-141 dose?
Community-reported protocols for PT-141 typically use 1.75 mg as needed via Subcutaneous. 1.75 mg is a common starting dose. Matches FDA-approved Vyleesi dosing; no more than one dose per 24 hours
Where do you inject PT-141?
PT-141 is typically injected subcutaneous. Common sites reported in the literature and by users include: Abdomen (FDA-approved site), Thigh (FDA-approved site). Rotate sites with each injection to reduce localized irritation.
Can I use sterile water instead of bacteriostatic water for PT-141?
Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like PT-141 because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.
More on PT-141
Medical Disclaimer
This website is for educational and informational purposes only. The information provided is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare professional before using any peptide or supplement.