Gonadorelin Dosing Calculator
Gonadorelin (GnRH): Hypothalamic reproductive hormone guide.
Pre-filled with the most-reported community reconstitution protocol for Gonadorelin. See how 1 mL and 2 mL of bacteriostatic water change concentration and syringe-draw volume, then adjust the calculator below for your own vial.
Quick answer · Community-reported standard
A 5 mg vial of Gonadorelin reconstituted with 1 mL of bacteriostatic water yields a concentration of 2.50 mg/mL. At that concentration, a 100 mcg dose of Gonadorelin equals 4 units on a U-100 insulin syringe (0.040 mL). Gonadorelin is typically administered every other day via subcutaneous.
Gonadorelin reconstitution: 1 mL vs 2 mL bac water
Bacteriostatic water volume is flexible. Less water means higher concentration and smaller injection volumes; more water means lower concentration and easier dose precision. Both options below are valid for a 5 mg vial.
| BAC water added | Concentration | Volume per 100 mcg dose | Draw on U-100 syringe (units) |
|---|---|---|---|
| 1 mL | 5.00 mg/mL | 0.020 mL | 2 units |
| 2 mL | 2.50 mg/mL | 0.040 mL | 4 units |
Calculate your Gonadorelin dose
Alternative Gonadorelin protocols
Beyond the default above, Gonadorelin is also reported in the following protocols. Use these as starting points and recalculate with the tool above.
Post Cycle Therapy Protocol
Community- Dose
- 100-200 mcg
- Frequency
- Daily for 3 days then 2-3 times weekly
- Duration
- 2-4 weeks
- Route
- Subcutaneous
Used after steroid cycles to restart endogenous testosterone; no more than 3 consecutive daily doses to avoid receptor desensitization
Conservative Low-Dose Protocol
Community- Dose
- 50-100 mcg
- Frequency
- 2-3 times weekly
- Duration
- Ongoing
- Route
- Subcutaneous
Lower dose approach; some clinics prescribe this range as standard
High-Frequency Micro-Dose Protocol
Community- Dose
- 20-50 mcg
- Frequency
- Multiple times daily
- Duration
- Ongoing
- Route
- Subcutaneous
Experimental approach to mimic natural pulsatile GnRH release; impractical for most users
Fertility Preservation During TRT
Clinical- Dose
- 100-200 mcg
- Frequency
- 2-3 times per week
- Duration
- Ongoing while on TRT
Pulsatile dosing critical to prevent receptor desensitization
Diagnostic GnRH Stimulation Test
Clinical- Dose
- 100 mcg (or 2.5 mcg/kg, max 100 mcg)
- Frequency
- Single IV bolus
- Duration
- Single administration with serial blood draws at 0, 30, 60, 120 min
Used to assess pituitary LH/FSH reserve
Gonadorelin reconstitution & storage
Reconstitute lyophilized gonadorelin with bacteriostatic water. Add water slowly along the vial wall. Do not shake. Typical reconstitution uses 1-2 mL per vial. Reconstituted solution is stable refrigerated for up to 14 days.
Store lyophilized powder at 2-8C (refrigerated). Protect from light. After reconstitution, store refrigerated and use within 14 days. Do not freeze reconstituted solution.
Gonadorelin dosing FAQ
How much bacteriostatic water should I add to a 5 mg vial of Gonadorelin?
The community standard is 1 mL of bacteriostatic water for a 5 mg Gonadorelin vial. That gives a concentration of 2.50 mg/mL, so a 100 mcg dose is 4 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 5.00 mg/mL and halves the draw to 2 units. Less water = smaller injection volume but harder to measure precisely.
How many syringe units is a 100 mcg dose of Gonadorelin?
On a standard U-100 insulin syringe, a 100 mcg dose of Gonadorelin is 4 units when the 5 mg vial is reconstituted with 1 mL of bacteriostatic water (2.50 mg/mL). If you use 1 mL of bac water instead, draw 2 units (5.00 mg/mL).
What is the standard Gonadorelin dose?
Community-reported protocols for Gonadorelin typically use 100 mcg–200 mcg every other day via Subcutaneous. 100 mcg is a common starting dose. Most commonly prescribed protocol as HCG alternative during TRT; co-administered with testosterone
How long does a vial of Gonadorelin last at 100 mcg every other day?
A 5 mg vial of Gonadorelin contains roughly 50 doses at 100 mcg per injection. At every other day dosing, that is approximately 100 days (about 14 weeks) of supply per vial. Reconstituted Gonadorelin should generally be used within 28 days when refrigerated.
Where do you inject Gonadorelin?
Gonadorelin is typically injected subcutaneous. Common sites reported in the literature and by users include: Subcutaneous (abdomen), Subcutaneous (thigh), Intravenous (diagnostic testing). Rotate sites with each injection to reduce localized irritation.
Can I use sterile water instead of bacteriostatic water for Gonadorelin?
Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Gonadorelin because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.
More on Gonadorelin
Gonadorelin overview
Mechanism of action, primary uses, and research summary
Gonadorelin dosing protocols
Full clinical and research-based dosing reference
Gonadorelin community protocols
Real-world usage patterns from peptide communities
Gonadorelin side effects
Reported adverse effects and safety considerations
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Medical Disclaimer
This website is for educational and informational purposes only. The information provided is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare professional before using any peptide or supplement.