Bivamelagon Dosing Calculator
Bivamelagon (LB54640): first oral MC4R agonist for hypothalamic obesity by Rhythm Pharmaceuticals.
Pre-filled with the most-reported clinical reconstitution protocol for Bivamelagon. See how 1 mL and 2 mL of bacteriostatic water change concentration and syringe-draw volume, then adjust the calculator below for your own vial.
Quick answer · Clinical protocol
A 15 mg vial of Bivamelagon reconstituted with 2 mL of bacteriostatic water yields a concentration of 7.50 mg/mL. At that concentration, a 400 mg dose of Bivamelagon equals 5333.3 units on a U-100 insulin syringe (53.333 mL). Bivamelagon is typically administered once daily.
Bivamelagon reconstitution: 1 mL vs 2 mL bac water
Bacteriostatic water volume is flexible. Less water means higher concentration and smaller injection volumes; more water means lower concentration and easier dose precision. Both options below are valid for a 15 mg vial.
| BAC water added | Concentration | Volume per 400 mg dose | Draw on U-100 syringe (units) |
|---|---|---|---|
| 1 mL | 15.00 mg/mL | 26.667 mL | 2666.7 units |
| 2 mL | 7.50 mg/mL | 53.333 mL | 5333.3 units |
Calculate your Bivamelagon dose
Bivamelagon reconstitution & storage
No reconstitution required. Bivamelagon is an oral tablet taken once daily.
Storage conditions not publicly disclosed. As a small molecule oral tablet, room temperature storage is expected.
Bivamelagon dosing FAQ
How much bacteriostatic water should I add to a 15 mg vial of Bivamelagon?
The community standard is 2 mL of bacteriostatic water for a 15 mg Bivamelagon vial. That gives a concentration of 7.50 mg/mL, so a 400 mg dose is 5333.3 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 15.00 mg/mL and halves the draw to 2666.7 units. Less water = smaller injection volume but harder to measure precisely.
How many syringe units is a 400 mg dose of Bivamelagon?
On a standard U-100 insulin syringe, a 400 mg dose of Bivamelagon is 5333.3 units when the 15 mg vial is reconstituted with 2 mL of bacteriostatic water (7.50 mg/mL). If you use 1 mL of bac water instead, draw 2666.7 units (15.00 mg/mL).
What is the standard Bivamelagon dose?
Clinical protocols for Bivamelagon typically use 400 mgâ600 mg once daily via subcutaneous injection. 400 mg is a common starting dose. The 600 mg dose achieved 9.3% BMI reduction at 14 weeks. The 400 mg dose achieved 7.7% BMI reduction. Hunger scores decreased by more than 2.8 points at both dose levels.
Where do you inject Bivamelagon?
Bivamelagon is typically administered subcutaneously. Common subcutaneous sites are the lower abdomen (at least an inch from the navel), the outer thigh, and the love handles. Rotate sites with each injection to reduce localized irritation and bruising.
Can I use sterile water instead of bacteriostatic water for Bivamelagon?
Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Bivamelagon because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.
More on Bivamelagon
Bivamelagon overview
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Bivamelagon dosing protocols
Full clinical and research-based dosing reference
Bivamelagon community protocols
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Bivamelagon side effects
Reported adverse effects and safety considerations
Medical Disclaimer
This website is for educational and informational purposes only. The information provided is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare professional before using any peptide or supplement.