KPV Dosing Calculator
KPV (Lys-Pro-Val): alpha-MSH-derived anti-inflammatory tripeptide.
Pre-filled with the most-reported community reconstitution protocol for KPV. See how 1 mL and 2 mL of bacteriostatic water change concentration and syringe-draw volume, then adjust the calculator below for your own vial.
Quick answer · Community-reported standard
A 5 mg vial of KPV reconstituted with 2 mL of bacteriostatic water yields a concentration of 2.50 mg/mL. At that concentration, a 200 mcg dose of KPV equals 8 units on a U-100 insulin syringe (0.080 mL). KPV is typically administered once daily via subcutaneous.
KPV reconstitution: 1 mL vs 2 mL bac water
Bacteriostatic water volume is flexible. Less water means higher concentration and smaller injection volumes; more water means lower concentration and easier dose precision. Both options below are valid for a 5 mg vial.
| BAC water added | Concentration | Volume per 200 mcg dose | Draw on U-100 syringe (units) |
|---|---|---|---|
| 1 mL | 5.00 mg/mL | 0.040 mL | 4 units |
| 2 mL | 2.50 mg/mL | 0.080 mL | 8 units |
Calculate your KPV dose
Alternative KPV protocols
Beyond the default above, KPV is also reported in the following protocols. Use these as starting points and recalculate with the tool above.
Oral Gut Protocol
Community- Dose
- 500-1000 mcg
- Frequency
- Twice daily
- Duration
- 4-8 weeks
- Route
- Oral
Oral capsule form for targeted gut inflammation; taken on empty stomach for PepT1 transporter uptake
SIBO/Gut Dysbiosis Protocol
Community- Dose
- 500 mcg
- Frequency
- Twice daily for 2 weeks then once daily
- Duration
- 4-6 weeks
- Route
- Oral
Front-loaded dose for gut-specific issues then reduced to maintenance
High-Dose Research Protocol
Community- Dose
- 10-20 mg
- Frequency
- Once daily
- Duration
- 2-4 weeks
- Route
- Subcutaneous
Experimental high-dose protocol reported in some practitioner settings; significantly above standard community doses
Preclinical Colitis Models (Mouse - Oral)
Clinical- Dose
- Various; typically administered in drinking water or by gavage
- Frequency
- Daily during disease induction period
- Duration
- 7-14 days in most colitis model studies
Preclinical only. Mouse studies using DSS and TNBS colitis models. No established human dosing.
Preclinical Colitis Models (Mouse - Nanoparticle Delivery)
Clinical- Dose
- KPV-loaded nanoparticles administered orally or rectally
- Frequency
- Daily during disease induction period
- Duration
- 7-14 days in colitis model studies
Preclinical only. Laroui et al. 2010 used alginate-chitosan nanoparticles for enhanced colonic delivery.
KPV reconstitution & storage
Reconstitute with bacteriostatic water. Add water slowly along vial wall. Do not shake. Use 1-2 mL per vial.
Lyophilized powder: Store at -20°C to 4°C. Reconstituted: Store at 2-8°C, use within 3-4 weeks. Protect from light.
KPV dosing FAQ
How much bacteriostatic water should I add to a 5 mg vial of KPV?
The community standard is 2 mL of bacteriostatic water for a 5 mg KPV vial. That gives a concentration of 2.50 mg/mL, so a 200 mcg dose is 8 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 5.00 mg/mL and halves the draw to 4 units. Less water = smaller injection volume but harder to measure precisely.
How many syringe units is a 200 mcg dose of KPV?
On a standard U-100 insulin syringe, a 200 mcg dose of KPV is 8 units when the 5 mg vial is reconstituted with 2 mL of bacteriostatic water (2.50 mg/mL). If you use 1 mL of bac water instead, draw 4 units (5.00 mg/mL).
What is the standard KPV dose?
Community-reported protocols for KPV typically use 200 mcg–500 mcg once daily via Subcutaneous. 200 mcg is a common starting dose. Most commonly reported protocol for general anti-inflammatory use; start at lower end
How long does a vial of KPV last at 200 mcg once daily?
A 5 mg vial of KPV contains roughly 25 doses at 200 mcg per injection. At once daily dosing, that is approximately 25 days (about 4 weeks) of supply per vial. Reconstituted KPV should generally be used within 28 days when refrigerated.
Where do you inject KPV?
KPV is typically administered subcutaneous. Common subcutaneous sites are the lower abdomen (at least an inch from the navel), the outer thigh, and the love handles. Rotate sites with each injection to reduce localized irritation and bruising.
Can I use sterile water instead of bacteriostatic water for KPV?
Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like KPV because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.
More on KPV
Medical Disclaimer
This website is for educational and informational purposes only. The information provided is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare professional before using any peptide or supplement.