Cortistatin Dosing Calculator

Dose

In rat studies, 0.1-1.0 nmol cortistatin-14 administered ICV produced dose-dependent increases in slow-wave sleep. These are research doses not applicable to human use.

Frequency

Single ICV injection in preclinical studies

Duration

Acute single-dose studies

ICV administration bypasses the blood-brain barrier. Sleep effects observed within minutes and lasted several hours. Not a clinically applicable route.

Dose

In mouse colitis models, cortistatin was administered at 1-5 nmol IP daily. In sepsis models, single-dose cortistatin at 5 nmol IP provided significant protection against endotoxemia.

Frequency

Daily IP injection in preclinical models

Duration

5-10 days in colitis studies

Systemic administration was effective for peripheral inflammatory conditions. Research doses are species-specific and not translatable to human dosing.

How much bacteriostatic water should I add to a 5 mg vial of Cortistatin?

The community standard is 1 mL of bacteriostatic water for a 5 mg Cortistatin vial. That gives a concentration of 2.50 mg/mL, so a 50 mcg dose is 2 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 5.00 mg/mL and halves the draw to 1 units. Less water = smaller injection volume but harder to measure precisely.

How many syringe units is a 50 mcg dose of Cortistatin?

On a standard U-100 insulin syringe, a 50 mcg dose of Cortistatin is 2 units when the 5 mg vial is reconstituted with 1 mL of bacteriostatic water (2.50 mg/mL). If you use 1 mL of bac water instead, draw 1 units (5.00 mg/mL).

What is the standard Cortistatin dose?

Community-reported protocols for Cortistatin typically use 50 mcg–200 mcg once daily via Subcutaneous. 50 mcg is a common starting dose. Extremely limited community use; doses extrapolated from preclinical literature and related somatostatin dosing

How long does a vial of Cortistatin last at 50 mcg once daily?

A 5 mg vial of Cortistatin contains roughly 100 doses at 50 mcg per injection. At once daily dosing, that is approximately 100 days (about 14 weeks) of supply per vial. Reconstituted Cortistatin should generally be used within 28 days when refrigerated.

Where do you inject Cortistatin?

Cortistatin is typically administered subcutaneous. Common subcutaneous sites are the lower abdomen (at least an inch from the navel), the outer thigh, and the love handles. Rotate sites with each injection to reduce localized irritation and bruising.

Can I use sterile water instead of bacteriostatic water for Cortistatin?

Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Cortistatin because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.