Pemvidutide Dosing Calculator

Dose

1.2 mg, 1.8 mg, or 2.4 mg once weekly subcutaneous injection. No dose titration required.

Frequency

Once weekly subcutaneous injection

Duration

48 weeks (Phase 2b trial)

The 2.4 mg dose achieved 15.6% total body weight loss at 48 weeks. 78.1% of weight loss was from fat mass. The 1.8 mg dose achieved approximately 11-12% weight loss.

How much bacteriostatic water should I add to a 5 mg vial of Pemvidutide?

The community standard is 2 mL of bacteriostatic water for a 5 mg Pemvidutide vial. That gives a concentration of 2.50 mg/mL, so a 1.2 mg dose is 48 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 5.00 mg/mL and halves the draw to 24 units. Less water = smaller injection volume but harder to measure precisely.

How many syringe units is a 1.2 mg dose of Pemvidutide?

On a standard U-100 insulin syringe, a 1.2 mg dose of Pemvidutide is 48 units when the 5 mg vial is reconstituted with 2 mL of bacteriostatic water (2.50 mg/mL). If you use 1 mL of bac water instead, draw 24 units (5.00 mg/mL).

What is the standard Pemvidutide dose?

Clinical protocols for Pemvidutide typically use 1.2 mg–1.8 mg once weekly via subcutaneous injection. 1.2 mg is a common starting dose. The 1.2 mg dose achieved 59.1% MASH resolution. The 1.8 mg dose achieved 54.7% liver fat reduction by MRI-PDFF at 48 weeks.

How long does a vial of Pemvidutide last at 1.2 mg once weekly?

A 5 mg vial of Pemvidutide contains roughly 4 doses at 1.2 mg per injection. At once weekly dosing, that is approximately 28 days (about 4 weeks) of supply per vial. Reconstituted Pemvidutide should generally be used within 28 days when refrigerated.

Where do you inject Pemvidutide?

Pemvidutide is typically injected subcutaneously. Common sites reported in the literature and by users include: Abdomen, Thigh, Upper arm. Rotate sites with each injection to reduce localized irritation.

Can I use sterile water instead of bacteriostatic water for Pemvidutide?

Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Pemvidutide because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.