CagriSema Dosing Calculator

Dose

Once-weekly subcutaneous injection. Target maintenance dose is cagrilintide 2.4 mg plus semaglutide 2.4 mg. Gradual dose escalation over approximately 16-20 weeks to reach target maintenance dose.

Frequency

Once weekly subcutaneous injection

Duration

68 weeks in Phase 3 trials; intended for long-term use

Co-administered as a single injection from a pre-filled pen. Dose escalation is required for both components to minimize GI side effects. Not yet FDA-approved.

Dose

Once-weekly subcutaneous injection. Target dose is cagrilintide 2.4 mg plus semaglutide 2.4 mg. Same dose escalation schedule as REDEFINE 1.

Frequency

Once weekly subcutaneous injection

Duration

68 weeks in Phase 3 trial

Produced 13.7% weight loss and HbA1c reductions with 73.5% achieving HbA1c of 6.5% or less. Background diabetes medications may need dose adjustment.

How much bacteriostatic water should I add to a 10 mg vial of CagriSema?

The community standard is 2 mL of bacteriostatic water for a 10 mg CagriSema vial. That gives a concentration of 5.00 mg/mL, so a 2.4 mg dose is 48 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 10.00 mg/mL and halves the draw to 24 units. Less water = smaller injection volume but harder to measure precisely.

How many syringe units is a 2.4 mg dose of CagriSema?

On a standard U-100 insulin syringe, a 2.4 mg dose of CagriSema is 48 units when the 10 mg vial is reconstituted with 2 mL of bacteriostatic water (5.00 mg/mL). If you use 1 mL of bac water instead, draw 24 units (10.00 mg/mL).

What is the standard CagriSema dose?

Community-reported protocols for CagriSema typically use 2.4 mg once weekly via Subcutaneous. 2.4 mg is a common starting dose. Community members attempt to replicate the clinical CagriSema combination by sourcing each component separately; carries significant dosing and quality risks

How long does a vial of CagriSema last at 2.4 mg once weekly?

A 10 mg vial of CagriSema contains roughly 4 doses at 2.4 mg per injection. At once weekly dosing, that is approximately 28 days (about 4 weeks) of supply per vial. Reconstituted CagriSema should generally be used within 28 days when refrigerated.

Where do you inject CagriSema?

CagriSema is typically injected subcutaneous. Common sites reported in the literature and by users include: Abdomen (at least 2 inches from navel), Front of thigh (middle third), Upper arm (back, upper outer area). Rotate sites with each injection to reduce localized irritation.

Can I use sterile water instead of bacteriostatic water for CagriSema?

Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like CagriSema because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.