Bioglutide (NA-931) Dosing Calculator

Dose

Ascending doses up to 150 mg daily in adults with obesity or overweight with comorbidities over 13 weeks. The 150 mg daily dose achieved maximum efficacy.

Frequency

Once daily oral capsule

Duration

13 weeks

Phase 2 study in 125 adults. Maximum mean weight loss of 13.8% at 150 mg daily. 72% of treated subjects achieved at least 12% weight loss. No fasting or food restrictions required.

Dose

NA-931 150 mg daily oral capsule combined with tirzepatide subcutaneous injection in adults with obesity or overweight. Designed to evaluate synergistic effects.

Frequency

NA-931 once daily oral; tirzepatide once weekly subcutaneous

Duration

Under investigation

Phase 2 study enrolling 224 participants. Designed to assess whether combination produces synergistic weight loss while reducing GI adverse events and preserving muscle mass. Preclinical studies showed synergistic effects on weight, glucose, and lipids.

How much bacteriostatic water should I add to a 15 mg vial of Bioglutide (NA-931)?

The community standard is 2 mL of bacteriostatic water for a 15 mg Bioglutide (NA-931) vial. That gives a concentration of 7.50 mg/mL, so a 150 mg dose is 2000 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 15.00 mg/mL and halves the draw to 1000 units. Less water = smaller injection volume but harder to measure precisely.

How many syringe units is a 150 mg dose of Bioglutide (NA-931)?

On a standard U-100 insulin syringe, a 150 mg dose of Bioglutide (NA-931) is 2000 units when the 15 mg vial is reconstituted with 2 mL of bacteriostatic water (7.50 mg/mL). If you use 1 mL of bac water instead, draw 1000 units (15.00 mg/mL).

What is the standard Bioglutide (NA-931) dose?

Clinical protocols for Bioglutide (NA-931) typically use 150 mg–28 mg once daily via subcutaneous injection. 150 mg is a common starting dose. Phase 1 study in 74 otherwise healthy overweight/obese adults. Dose-dependent weight loss up to 6.4% at Day 28. Weight loss maintained or improved at Day 35 (7 days post-last dose).

Where do you inject Bioglutide (NA-931)?

Bioglutide (NA-931) is typically administered subcutaneously. Common subcutaneous sites are the lower abdomen (at least an inch from the navel), the outer thigh, and the love handles. Rotate sites with each injection to reduce localized irritation and bruising.

Can I use sterile water instead of bacteriostatic water for Bioglutide (NA-931)?

Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Bioglutide (NA-931) because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.