Zilucoplan Dosing Calculator

Dose

0.3 mg/kg body weight subcutaneously once daily. Weight-based dosing with pre-filled syringes available in multiple strengths.

Frequency

Once daily subcutaneous self-injection

Duration

Ongoing (chronic treatment for gMG management)

FDA-approved dose. Steady-state trough concentrations reached by 4 weeks. Achieves approximately 97.5% complement inhibition by end of first week. Meningococcal vaccination required at least 2 weeks before first dose.

How much bacteriostatic water should I add to a 5 mg vial of Zilucoplan?

The community standard is 2 mL of bacteriostatic water for a 5 mg Zilucoplan vial. That gives a concentration of 2.50 mg/mL, so a 300 mcg dose is 12 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 5.00 mg/mL and halves the draw to 6 units. Less water = smaller injection volume but harder to measure precisely.

How many syringe units is a 300 mcg dose of Zilucoplan?

On a standard U-100 insulin syringe, a 300 mcg dose of Zilucoplan is 12 units when the 5 mg vial is reconstituted with 2 mL of bacteriostatic water (2.50 mg/mL). If you use 1 mL of bac water instead, draw 6 units (5.00 mg/mL).

What is the standard Zilucoplan dose?

Community-reported protocols for Zilucoplan typically use 0.3 mg once daily via Subcutaneous self-injection. 300 mcg is a common starting dose. FDA-approved dosing; self-administered via prefilled syringe after training by healthcare provider

How long does a vial of Zilucoplan last at 300 mcg once daily?

A 5 mg vial of Zilucoplan contains roughly 16 doses at 300 mcg per injection. At once daily dosing, that is approximately 16 days (about 2 weeks) of supply per vial. Reconstituted Zilucoplan should generally be used within 28 days when refrigerated.

Where do you inject Zilucoplan?

Zilucoplan is typically injected subcutaneous self-injection. Common sites reported in the literature and by users include: Abdomen, Thigh, Upper arm (outer area). Rotate sites with each injection to reduce localized irritation.

Can I use sterile water instead of bacteriostatic water for Zilucoplan?

Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Zilucoplan because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.