Pegcetacoplan Dosing Calculator

Dose

15 mg/0.1 mL

Frequency

Monthly or every other month

Duration

Ongoing

Route

Intravitreal injection

Administered by retinal specialist in clinic; first complement inhibitor for dry AMD

Dose

1,080 mg subcutaneously twice weekly. Self-administered via infusion pump over approximately 20-30 minutes per infusion.

Frequency

Twice weekly (every 3-4 days) subcutaneous infusion

Duration

Ongoing (chronic treatment for PNH management)

FDA-approved dose. When transitioning from eculizumab, administer pegcetacoplan concomitantly with eculizumab for the first 4 weeks. Vaccination against encapsulated bacteria required before treatment.

Dose

15 mg (0.1 mL of 150 mg/mL solution) by intravitreal injection. Monthly or every other month dosing schedules approved.

Frequency

Monthly or every other month intravitreal injection

Duration

Ongoing (chronic treatment for GA progression)

FDA-approved dose. Administered by an ophthalmologist or retinal specialist in a clinical setting. Monthly dosing showed numerically greater effect size than every-other-month dosing in trials.

How much bacteriostatic water should I add to a 15 mg vial of Pegcetacoplan?

The community standard is 2 mL of bacteriostatic water for a 15 mg Pegcetacoplan vial. That gives a concentration of 7.50 mg/mL, so a 1 mg dose is 13.3 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 15.00 mg/mL and halves the draw to 6.7 units. Less water = smaller injection volume but harder to measure precisely.

How many syringe units is a 1 mg dose of Pegcetacoplan?

On a standard U-100 insulin syringe, a 1 mg dose of Pegcetacoplan is 13.3 units when the 15 mg vial is reconstituted with 2 mL of bacteriostatic water (7.50 mg/mL). If you use 1 mL of bac water instead, draw 6.7 units (15.00 mg/mL).

What is the standard Pegcetacoplan dose?

Community-reported protocols for Pegcetacoplan typically use 1 mg–80 mg once weekly via Subcutaneous infusion. 1 mg is a common starting dose. Self-administered SC infusion at home; some patients use infusion pumps for convenience

How long does a vial of Pegcetacoplan last at 1 mg once weekly?

A 15 mg vial of Pegcetacoplan contains roughly 15 doses at 1 mg per injection. At once weekly dosing, that is approximately 105 days (about 15 weeks) of supply per vial. Reconstituted Pegcetacoplan should generally be used within 28 days when refrigerated.

Where do you inject Pegcetacoplan?

Pegcetacoplan is typically injected subcutaneous infusion. Common sites reported in the literature and by users include: Abdomen, Thigh, Upper arm (outer area), Intravitreal (Syfovre only, by specialist). Rotate sites with each injection to reduce localized irritation.

Can I use sterile water instead of bacteriostatic water for Pegcetacoplan?

Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Pegcetacoplan because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.