Teduglutide Dosing Calculator

Dose

0.05 mg/kg once daily

Frequency

Once daily

Duration

Ongoing

Route

Subcutaneous injection

FDA-approved for pediatric patients 1 year and older with SBS-IF requiring parenteral support

Dose

0.05 mg/kg body weight subcutaneous injection once daily. Dose adjustment required for renal impairment (CrCl less than 50 mL/min): reduce to 0.025 mg/kg once daily.

Frequency

Once daily

Duration

Continuous long-term treatment. Efficacy reassessed periodically with parenteral nutrition optimization.

Colonoscopy required before initiation and within 1-2 years of starting treatment, then every 5 years. Monitor for intestinal polyps, biliary disease, and fluid/electrolyte changes.

Dose

0.05 mg/kg body weight subcutaneous injection once daily. Same renal dose adjustment applies.

Frequency

Once daily

Duration

Continuous treatment with regular growth monitoring and parenteral nutrition optimization.

Approved for patients 1 year and older based on Phase 3 pediatric data. Monitor growth parameters in addition to standard safety assessments.

How much bacteriostatic water should I add to a 5 mg vial of Teduglutide?

The community standard is 1 mL of bacteriostatic water for a 5 mg Teduglutide vial. That gives a concentration of 2.50 mg/mL, so a 50 mcg dose is 2 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 5.00 mg/mL and halves the draw to 1 units. Less water = smaller injection volume but harder to measure precisely.

How many syringe units is a 50 mcg dose of Teduglutide?

On a standard U-100 insulin syringe, a 50 mcg dose of Teduglutide is 2 units when the 5 mg vial is reconstituted with 1 mL of bacteriostatic water (2.50 mg/mL). If you use 1 mL of bac water instead, draw 1 units (5.00 mg/mL).

What is the standard Teduglutide dose?

Community-reported protocols for Teduglutide typically use 0.05 mg once daily via Subcutaneous injection. 50 mcg is a common starting dose. FDA-approved dose for adults with SBS-IF; dose reduction to 0.025 mg/kg for moderate-severe renal impairment

How long does a vial of Teduglutide last at 50 mcg once daily?

A 5 mg vial of Teduglutide contains roughly 100 doses at 50 mcg per injection. At once daily dosing, that is approximately 100 days (about 14 weeks) of supply per vial. Reconstituted Teduglutide should generally be used within 28 days when refrigerated.

Where do you inject Teduglutide?

Teduglutide is typically injected subcutaneous injection. Common sites reported in the literature and by users include: Abdomen (alternating quadrants), Thighs (alternating legs), Upper arms (alternating arms). Rotate sites with each injection to reduce localized irritation.

Can I use sterile water instead of bacteriostatic water for Teduglutide?

Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Teduglutide because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.