Glepaglutide Dosing Calculator
Glepaglutide (ZP1848): long-acting GLP-2 analog for short bowel syndrome.
Pre-filled with the most-reported clinical reconstitution protocol for Glepaglutide. See how 1 mL and 2 mL of bacteriostatic water change concentration and syringe-draw volume, then adjust the calculator below for your own vial.
Quick answer · Clinical protocol
A 10 mg vial of Glepaglutide reconstituted with 2 mL of bacteriostatic water yields a concentration of 5.00 mg/mL. At that concentration, a 10 mg dose of Glepaglutide equals 200 units on a U-100 insulin syringe (2.000 mL). Glepaglutide is typically administered twice weekly.
Glepaglutide reconstitution: 1 mL vs 2 mL bac water
Bacteriostatic water volume is flexible. Less water means higher concentration and smaller injection volumes; more water means lower concentration and easier dose precision. Both options below are valid for a 10 mg vial.
| BAC water added | Concentration | Volume per 10 mg dose | Draw on U-100 syringe (units) |
|---|---|---|---|
| 1 mL | 10.00 mg/mL | 1.000 mL | 100 units |
| 2 mL | 5.00 mg/mL | 2.000 mL | 200 units |
Calculate your Glepaglutide dose
Glepaglutide reconstitution & storage
Glepaglutide is formulated as a ready-to-use liquid solution in an autoinjector device. No reconstitution is required, which represents a significant practical advantage over teduglutide (which requires daily reconstitution from lyophilized powder). This was a deliberate design goal enabled by the chemical stability of glepaglutide in aqueous solution.
Store refrigerated at 2-8 degrees C. The ready-to-use formulation has demonstrated acceptable stability for the shelf life required for commercial use. Protect from light. Do not freeze.
Glepaglutide dosing FAQ
How much bacteriostatic water should I add to a 10 mg vial of Glepaglutide?
The community standard is 2 mL of bacteriostatic water for a 10 mg Glepaglutide vial. That gives a concentration of 5.00 mg/mL, so a 10 mg dose is 200 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 10.00 mg/mL and halves the draw to 100 units. Less water = smaller injection volume but harder to measure precisely.
How many syringe units is a 10 mg dose of Glepaglutide?
On a standard U-100 insulin syringe, a 10 mg dose of Glepaglutide is 200 units when the 10 mg vial is reconstituted with 2 mL of bacteriostatic water (5.00 mg/mL). If you use 1 mL of bac water instead, draw 100 units (10.00 mg/mL).
What is the standard Glepaglutide dose?
Clinical protocols for Glepaglutide typically use 10 mgâ3 mg twice weekly via subcutaneous injection. 10 mg is a common starting dose. Once-weekly dosing of 10 mg was also tested but did not achieve statistical significance vs placebo. Twice-weekly dosing is the regimen supported by phase 3 data.
How long does a vial of Glepaglutide last at 10 mg twice weekly?
A 10 mg vial of Glepaglutide contains roughly 1 doses at 10 mg per injection. At twice weekly dosing, that is approximately 4 days (about 1 weeks) of supply per vial. Reconstituted Glepaglutide should generally be used within 28 days when refrigerated.
Where do you inject Glepaglutide?
Glepaglutide is typically injected subcutaneously. Common sites reported in the literature and by users include: Abdomen, Thigh. Rotate sites with each injection to reduce localized irritation.
Can I use sterile water instead of bacteriostatic water for Glepaglutide?
Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Glepaglutide because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.
More on Glepaglutide
Glepaglutide overview
Mechanism of action, primary uses, and research summary
Glepaglutide dosing protocols
Full clinical and research-based dosing reference
Glepaglutide community protocols
Real-world usage patterns from peptide communities
Glepaglutide side effects
Reported adverse effects and safety considerations
Medical Disclaimer
This website is for educational and informational purposes only. The information provided is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare professional before using any peptide or supplement.