Sermorelin Dosing Calculator
Sermorelin: GHRH(1-29) analog for growth hormone stimulation.
Pre-filled with the most-reported community reconstitution protocol for Sermorelin. See how 1 mL and 2 mL of bacteriostatic water change concentration and syringe-draw volume, then adjust the calculator below for your own vial.
Quick answer · Community-reported standard
A 5 mg vial of Sermorelin reconstituted with 2 mL of bacteriostatic water yields a concentration of 2.50 mg/mL. At that concentration, a 200 mcg dose of Sermorelin equals 8 units on a U-100 insulin syringe (0.080 mL). Sermorelin is typically administered once daily via subcutaneous.
Sermorelin reconstitution: 1 mL vs 2 mL bac water
Bacteriostatic water volume is flexible. Less water means higher concentration and smaller injection volumes; more water means lower concentration and easier dose precision. Both options below are valid for a 5 mg vial.
| BAC water added | Concentration | Volume per 200 mcg dose | Draw on U-100 syringe (units) |
|---|---|---|---|
| 1 mL | 5.00 mg/mL | 0.040 mL | 4 units |
| 2 mL | 2.50 mg/mL | 0.080 mL | 8 units |
Calculate your Sermorelin dose
Alternative Sermorelin protocols
Beyond the default above, Sermorelin is also reported in the following protocols. Use these as starting points and recalculate with the tool above.
Clinical/Compounding Pharmacy Protocol
Community- Dose
- 500-1000 mcg
- Frequency
- Once daily (before bed)
- Duration
- 6-12 months
- Route
- Subcutaneous
Higher dose often prescribed by anti-aging and TRT clinics; 1 mg dose reported as maximum pituitary stimulation threshold
Sermorelin + Ipamorelin Stack
Community- Dose
- 200-300 mcg each
- Frequency
- Once daily (before bed)
- Duration
- 3-6 months
- Route
- Subcutaneous
Combined GHRH + GHRP protocol targeting both GH-releasing pathways; five days on, two days off cycling common
Maintenance Protocol
Community- Dose
- 500-1000 mcg
- Frequency
- 2-3 times per week
- Duration
- Ongoing
- Route
- Subcutaneous
Used after initial daily loading phase of 3-6 months; reduced frequency to maintain elevated IGF-1 levels
Pediatric GH deficiency (FDA-approved dose)
Clinical- Dose
- 30 mcg/kg
- Frequency
- Once daily at bedtime
- Duration
- 12+ months with growth monitoring
Subcutaneous injection; dose based on body weight; formerly approved protocol
Adult GH stimulation (research protocol)
Clinical- Dose
- 100-300 mcg
- Frequency
- Once daily at bedtime
- Duration
- 3-6 months, cyclical
Subcutaneous injection; bedtime administration aligns with natural GH pulse
Sermorelin reconstitution & storage
Reconstitute lyophilized sermorelin with bacteriostatic water for injection (0.9% benzyl alcohol preserved). Add diluent slowly to the side of the vial to avoid foaming. Typical reconstitution is 2-3 mL per 5 mg vial. Gently swirl; do not shake. Allow complete dissolution before use.
Store lyophilized powder at controlled room temperature (20-25C) or refrigerated (2-8C). After reconstitution, refrigerate at 2-8C and use within 14 days. Do not freeze reconstituted solution. Protect from light.
Sermorelin dosing FAQ
How much bacteriostatic water should I add to a 5 mg vial of Sermorelin?
The community standard is 2 mL of bacteriostatic water for a 5 mg Sermorelin vial. That gives a concentration of 2.50 mg/mL, so a 200 mcg dose is 8 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 5.00 mg/mL and halves the draw to 4 units. Less water = smaller injection volume but harder to measure precisely.
How many syringe units is a 200 mcg dose of Sermorelin?
On a standard U-100 insulin syringe, a 200 mcg dose of Sermorelin is 8 units when the 5 mg vial is reconstituted with 2 mL of bacteriostatic water (2.50 mg/mL). If you use 1 mL of bac water instead, draw 4 units (5.00 mg/mL).
What is the standard Sermorelin dose?
Community-reported protocols for Sermorelin typically use 200 mcg–300 mcg once daily via Subcutaneous. 200 mcg is a common starting dose. Most commonly reported protocol; injected 30-60 minutes before sleep on an empty stomach to align with natural GH pulsatility
How long does a vial of Sermorelin last at 200 mcg once daily?
A 5 mg vial of Sermorelin contains roughly 25 doses at 200 mcg per injection. At once daily dosing, that is approximately 25 days (about 4 weeks) of supply per vial. Reconstituted Sermorelin should generally be used within 28 days when refrigerated.
Where do you inject Sermorelin?
Sermorelin is typically injected subcutaneous. Common sites reported in the literature and by users include: Abdomen (2 inches from navel), Thigh (outer quadricep), Upper arm (deltoid area). Rotate sites with each injection to reduce localized irritation.
Can I use sterile water instead of bacteriostatic water for Sermorelin?
Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Sermorelin because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.
More on Sermorelin
Sermorelin overview
Mechanism of action, primary uses, and research summary
Sermorelin dosing protocols
Full clinical and research-based dosing reference
Sermorelin community protocols
Real-world usage patterns from peptide communities
Sermorelin side effects
Reported adverse effects and safety considerations
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Medical Disclaimer
This website is for educational and informational purposes only. The information provided is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare professional before using any peptide or supplement.