Ibutamoren (MK-677) Dosing Calculator
Ibutamoren (MK-677): oral ghrelin receptor agonist and growth hormone secretagogue.
Pre-filled with the most-reported clinical reconstitution protocol for Ibutamoren (MK-677). See how 1 mL and 2 mL of bacteriostatic water change concentration and syringe-draw volume, then adjust the calculator below for your own vial.
Quick answer · Clinical protocol
A 15 mg vial of Ibutamoren (MK-677) reconstituted with 2 mL of bacteriostatic water yields a concentration of 7.50 mg/mL. At that concentration, a 25 mg dose of Ibutamoren (MK-677) equals 333.3 units on a U-100 insulin syringe (3.333 mL). Ibutamoren (MK-677) is typically administered once daily.
Ibutamoren (MK-677) reconstitution: 1 mL vs 2 mL bac water
Bacteriostatic water volume is flexible. Less water means higher concentration and smaller injection volumes; more water means lower concentration and easier dose precision. Both options below are valid for a 15 mg vial.
| BAC water added | Concentration | Volume per 25 mg dose | Draw on U-100 syringe (units) |
|---|---|---|---|
| 1 mL | 15.00 mg/mL | 1.667 mL | 166.7 units |
| 2 mL | 7.50 mg/mL | 3.333 mL | 333.3 units |
Calculate your Ibutamoren (MK-677) dose
Alternative Ibutamoren (MK-677) protocols
Beyond the default above, Ibutamoren (MK-677) is also reported in the following protocols. Use these as starting points and recalculate with the tool above.
Standard Oral Protocol
Community- Dose
- 25 mg
- Frequency
- Once daily
- Duration
- 8-16 weeks
- Route
- Oral
Most commonly reported dose; taken orally as capsule or liquid, typically in the morning or before bed
Beginner/Low-Dose Protocol
Community- Dose
- 10-15 mg
- Frequency
- Once daily
- Duration
- 8-12 weeks
- Route
- Oral
Starting dose to assess tolerance; allows evaluation of appetite and water retention side effects before increasing
Sleep-Optimized Protocol
Community- Dose
- 12.5-25 mg
- Frequency
- Once daily before bed
- Duration
- 8-16 weeks
- Route
- Oral
Pre-bed dosing to leverage nocturnal GH pulse and minimize daytime appetite effects
Extended Low-Dose Protocol
Community- Dose
- 10-12.5 mg
- Frequency
- Once daily
- Duration
- 3-6 months
- Route
- Oral
Lower dose for extended use; some users run continuously for 6+ months for anti-aging benefits
Hip Fracture Recovery (Clinical Trial Protocol)
Clinical- Dose
- 25 mg oral once daily. Used in the Adunsky et al. trial in elderly patients recovering from hip fracture surgery.
- Frequency
- Once daily oral administration
- Duration
- 24 weeks (trial stopped early due to safety concerns)
Trial was terminated early due to increased congestive heart failure rates in the ibutamoren group (6.5% vs 1.7% placebo).
Ibutamoren (MK-677) reconstitution & storage
Not applicable. Ibutamoren is an orally administered small molecule, not an injectable peptide. In clinical trials, it was supplied as oral capsules requiring no reconstitution or preparation.
In clinical trials, ibutamoren capsules were stored at controlled room temperature (15-30 degrees C / 59-86 degrees F) in original containers protected from moisture and light. As an unapproved investigational compound, no commercial storage guidelines exist.
Ibutamoren (MK-677) dosing FAQ
How much bacteriostatic water should I add to a 15 mg vial of Ibutamoren (MK-677)?
The community standard is 2 mL of bacteriostatic water for a 15 mg Ibutamoren (MK-677) vial. That gives a concentration of 7.50 mg/mL, so a 25 mg dose is 333.3 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 15.00 mg/mL and halves the draw to 166.7 units. Less water = smaller injection volume but harder to measure precisely.
How many syringe units is a 25 mg dose of Ibutamoren (MK-677)?
On a standard U-100 insulin syringe, a 25 mg dose of Ibutamoren (MK-677) is 333.3 units when the 15 mg vial is reconstituted with 2 mL of bacteriostatic water (7.50 mg/mL). If you use 1 mL of bac water instead, draw 166.7 units (15.00 mg/mL).
What is the standard Ibutamoren (MK-677) dose?
Clinical protocols for Ibutamoren (MK-677) typically use 25 mgâ2008 mg once daily via subcutaneous injection. 25 mg is a common starting dose. Not an approved medication. 25 mg daily was the most commonly studied dose in clinical trials. Produced sustained GH and IGF-1 elevation over 12 months.
Where do you inject Ibutamoren (MK-677)?
Ibutamoren (MK-677) is typically administered subcutaneously. Common subcutaneous sites are the lower abdomen (at least an inch from the navel), the outer thigh, and the love handles. Rotate sites with each injection to reduce localized irritation and bruising.
Can I use sterile water instead of bacteriostatic water for Ibutamoren (MK-677)?
Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Ibutamoren (MK-677) because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.
More on Ibutamoren (MK-677)
Ibutamoren (MK-677) overview
Mechanism of action, primary uses, and research summary
Ibutamoren (MK-677) dosing protocols
Full clinical and research-based dosing reference
Ibutamoren (MK-677) community protocols
Real-world usage patterns from peptide communities
Ibutamoren (MK-677) side effects
Reported adverse effects and safety considerations
Medical Disclaimer
This website is for educational and informational purposes only. The information provided is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare professional before using any peptide or supplement.