Petrelintide Dosing Calculator
Pre-filled with the most-reported clinical reconstitution protocol for Petrelintide. See how 1 mL and 2 mL of bacteriostatic water change concentration and syringe-draw volume, then adjust the calculator below for your own vial.
Quick answer · Clinical protocol
A 20 mg vial of Petrelintide reconstituted with 2 mL of bacteriostatic water yields a concentration of 10.00 mg/mL. At that concentration, a 4.8 mg dose of Petrelintide equals 48 units on a U-100 insulin syringe (0.480 mL). Petrelintide is typically administered once weekly.
Petrelintide reconstitution: 1 mL vs 2 mL bac water
Bacteriostatic water volume is flexible. Less water means higher concentration and smaller injection volumes; more water means lower concentration and easier dose precision. Both options below are valid for a 20 mg vial.
| BAC water added | Concentration | Volume per 4.8 mg dose | Draw on U-100 syringe (units) |
|---|---|---|---|
| 1 mL | 20.00 mg/mL | 0.240 mL | 24 units |
| 2 mL | 10.00 mg/mL | 0.480 mL | 48 units |
Calculate your Petrelintide dose
Alternative Petrelintide protocols
Beyond the default above, Petrelintide is also reported in the following protocols. Use these as starting points and recalculate with the tool above.
Weight Management (ZUPREME Phase 2b)
Clinical- Dose
- Multiple dose levels under evaluation in ZUPREME-1 (monotherapy) and ZUPREME-2 (combination with GLP-1 agonist). Specific doses not yet disclosed.
- Frequency
- Once weekly subcutaneous injection
- Duration
- Phase 2b trial (duration not disclosed)
ZUPREME-1 evaluates petrelintide monotherapy. ZUPREME-2 evaluates combination with a GLP-1 receptor agonist for enhanced weight loss.
Petrelintide reconstitution & storage
Reconstitution details not publicly disclosed. Petrelintide is administered as a once-weekly subcutaneous injection.
Storage conditions not publicly disclosed. As an acylated peptide, refrigerated storage (2-8 degrees C) is expected.
Petrelintide dosing FAQ
How much bacteriostatic water should I add to a 20 mg vial of Petrelintide?
The community standard is 2 mL of bacteriostatic water for a 20 mg Petrelintide vial. That gives a concentration of 10.00 mg/mL, so a 4.8 mg dose is 48 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 20.00 mg/mL and halves the draw to 24 units. Less water = smaller injection volume but harder to measure precisely.
How many syringe units is a 4.8 mg dose of Petrelintide?
On a standard U-100 insulin syringe, a 4.8 mg dose of Petrelintide is 48 units when the 20 mg vial is reconstituted with 2 mL of bacteriostatic water (10.00 mg/mL). If you use 1 mL of bac water instead, draw 24 units (20.00 mg/mL).
What is the standard Petrelintide dose?
Clinical protocols for Petrelintide typically use 4.8 mg once weekly via subcutaneous injection. 4.8 mg is a common starting dose. The 4.8 mg dose achieved 8.6% body weight loss over 16 once-weekly doses. Well tolerated with no dose-limiting toxicities reported.
How long does a vial of Petrelintide last at 4.8 mg once weekly?
A 20 mg vial of Petrelintide contains roughly 4 doses at 4.8 mg per injection. At once weekly dosing, that is approximately 28 days (about 4 weeks) of supply per vial. Reconstituted Petrelintide should generally be used within 28 days when refrigerated.
Where do you inject Petrelintide?
Petrelintide is typically injected subcutaneously. Common sites reported in the literature and by users include: Abdomen, Thigh, Upper arm. Rotate sites with each injection to reduce localized irritation.
Can I use sterile water instead of bacteriostatic water for Petrelintide?
Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Petrelintide because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.
More on Petrelintide
Medical Disclaimer
This website is for educational and informational purposes only. The information provided is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare professional before using any peptide or supplement.