Petrelintide Dosing Calculator

Dose

Multiple dose levels under evaluation in ZUPREME-1 (monotherapy) and ZUPREME-2 (combination with GLP-1 agonist). Specific doses not yet disclosed.

Frequency

Once weekly subcutaneous injection

Duration

Phase 2b trial (duration not disclosed)

ZUPREME-1 evaluates petrelintide monotherapy. ZUPREME-2 evaluates combination with a GLP-1 receptor agonist for enhanced weight loss.

How much bacteriostatic water should I add to a 10 mg vial of Petrelintide?

The community standard is 2 mL of bacteriostatic water for a 10 mg Petrelintide vial. That gives a concentration of 5.00 mg/mL, so a 4.8 mg dose is 96 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 10.00 mg/mL and halves the draw to 48 units. Less water = smaller injection volume but harder to measure precisely.

How many syringe units is a 4.8 mg dose of Petrelintide?

On a standard U-100 insulin syringe, a 4.8 mg dose of Petrelintide is 96 units when the 10 mg vial is reconstituted with 2 mL of bacteriostatic water (5.00 mg/mL). If you use 1 mL of bac water instead, draw 48 units (10.00 mg/mL).

What is the standard Petrelintide dose?

Clinical protocols for Petrelintide typically use 4.8 mg once weekly via subcutaneous injection. 4.8 mg is a common starting dose. The 4.8 mg dose achieved 8.6% body weight loss over 16 once-weekly doses. Well tolerated with no dose-limiting toxicities reported.

How long does a vial of Petrelintide last at 4.8 mg once weekly?

A 10 mg vial of Petrelintide contains roughly 2 doses at 4.8 mg per injection. At once weekly dosing, that is approximately 14 days (about 2 weeks) of supply per vial. Reconstituted Petrelintide should generally be used within 28 days when refrigerated.

Where do you inject Petrelintide?

Petrelintide is typically injected subcutaneously. Common sites reported in the literature and by users include: Abdomen, Thigh, Upper arm. Rotate sites with each injection to reduce localized irritation.

Can I use sterile water instead of bacteriostatic water for Petrelintide?

Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Petrelintide because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.