Cagrilintide Dosing Calculator
Cagrilintide: Long-acting amylin analog for obesity.
Pre-filled with the most-reported community reconstitution protocol for Cagrilintide. See how 1 mL and 2 mL of bacteriostatic water change concentration and syringe-draw volume, then adjust the calculator below for your own vial.
Quick answer · Community-reported standard
A 10 mg vial of Cagrilintide reconstituted with 2 mL of bacteriostatic water yields a concentration of 5.00 mg/mL. At that concentration, a 300 mcg dose of Cagrilintide equals 6 units on a U-100 insulin syringe (0.060 mL). Cagrilintide is typically administered once weekly via subcutaneous.
Cagrilintide reconstitution: 1 mL vs 2 mL bac water
Bacteriostatic water volume is flexible. Less water means higher concentration and smaller injection volumes; more water means lower concentration and easier dose precision. Both options below are valid for a 10 mg vial.
| BAC water added | Concentration | Volume per 300 mcg dose | Draw on U-100 syringe (units) |
|---|---|---|---|
| 1 mL | 10.00 mg/mL | 0.030 mL | 3 units |
| 2 mL | 5.00 mg/mL | 0.060 mL | 6 units |
Calculate your Cagrilintide dose
Alternative Cagrilintide protocols
Beyond the default above, Cagrilintide is also reported in the following protocols. Use these as starting points and recalculate with the tool above.
Phase 2 Monotherapy Dose-Finding (Lau et al., 2021)
Clinical- Dose
- 0.3 mg to 4.5 mg weekly (dose-dependent)
- Frequency
- Once weekly
- Duration
- 26 weeks
Subcutaneous injection; dose-dependent weight loss observed across all dose levels; 4.5 mg produced greatest weight loss (10.8%)
CagriSema Combination Protocol (Phase 2)
Clinical- Dose
- Cagrilintide 2.4 mg + semaglutide 2.4 mg
- Frequency
- Once weekly
- Duration
- 20 weeks (phase 2); 68 weeks (phase 3)
Both components administered as separate subcutaneous injections or combined in a single injection device; gradual dose titration required for both components
Dose Titration Schedule
Clinical- Dose
- Starting 0.25 mg, escalating to target dose over 16-20 weeks
- Frequency
- Once weekly with dose increases every 4 weeks
- Duration
- 16-20 week titration period
Gradual dose escalation essential to minimize gastrointestinal side effects; typical schedule mirrors semaglutide titration approach
Cagrilintide reconstitution & storage
Cagrilintide is supplied as a ready-to-use solution in prefilled pen devices; no reconstitution required. The solution should be clear and colorless to slightly yellow.
Store prefilled pens at 2-8C. In-use pens may be stored at room temperature (up to 30C) for up to 6 weeks. Protect from light. Do not freeze.
Cagrilintide dosing FAQ
How much bacteriostatic water should I add to a 10 mg vial of Cagrilintide?
The community standard is 2 mL of bacteriostatic water for a 10 mg Cagrilintide vial. That gives a concentration of 5.00 mg/mL, so a 300 mcg dose is 6 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 10.00 mg/mL and halves the draw to 3 units. Less water = smaller injection volume but harder to measure precisely.
How many syringe units is a 300 mcg dose of Cagrilintide?
On a standard U-100 insulin syringe, a 300 mcg dose of Cagrilintide is 6 units when the 10 mg vial is reconstituted with 2 mL of bacteriostatic water (5.00 mg/mL). If you use 1 mL of bac water instead, draw 3 units (10.00 mg/mL).
What is the standard Cagrilintide dose?
Community-reported protocols for Cagrilintide typically use 0.3 mgâ4.5 mg once weekly via Subcutaneous. 300 mcg is a common starting dose. Based on Phase 2 trial doses; community users attempting to replicate clinical escalation schedules; limited availability from research chemical suppliers
How long does a vial of Cagrilintide last at 300 mcg once weekly?
A 10 mg vial of Cagrilintide contains roughly 33 doses at 300 mcg per injection. At once weekly dosing, that is approximately 231 days (about 33 weeks) of supply per vial. Reconstituted Cagrilintide should generally be used within 28 days when refrigerated.
Where do you inject Cagrilintide?
Cagrilintide is typically injected subcutaneous. Common sites reported in the literature and by users include: Subcutaneous (abdomen), Subcutaneous (thigh), Subcutaneous (upper arm). Rotate sites with each injection to reduce localized irritation.
Can I use sterile water instead of bacteriostatic water for Cagrilintide?
Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Cagrilintide because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.
More on Cagrilintide
Cagrilintide overview
Mechanism of action, primary uses, and research summary
Cagrilintide dosing protocols
Full clinical and research-based dosing reference
Cagrilintide community protocols
Real-world usage patterns from peptide communities
Cagrilintide side effects
Reported adverse effects and safety considerations
Medical Disclaimer
This website is for educational and informational purposes only. The information provided is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare professional before using any peptide or supplement.