Oveporexton Dosing Calculator

Dose

Two dose groups evaluated: 1 mg twice daily and 2 mg twice daily (with placebo comparator). Both doses met all primary and secondary endpoints.

Frequency

Twice daily oral administration

Duration

12 weeks (Phase 3 trial duration)

The majority of participants on the 2 mg BID dose achieved wakefulness within normative range (MWT 20 minutes or more) and approximately 85% achieved ESS scores of 10 or less, comparable to healthy individuals. Cataplexy reduced by more than 80%.

How much bacteriostatic water should I add to a 5 mg vial of Oveporexton?

The community standard is 2 mL of bacteriostatic water for a 5 mg Oveporexton vial. That gives a concentration of 2.50 mg/mL, so a 500 mcg dose is 20 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 5.00 mg/mL and halves the draw to 10 units. Less water = smaller injection volume but harder to measure precisely.

How many syringe units is a 500 mcg dose of Oveporexton?

On a standard U-100 insulin syringe, a 500 mcg dose of Oveporexton is 20 units when the 5 mg vial is reconstituted with 2 mL of bacteriostatic water (2.50 mg/mL). If you use 1 mL of bac water instead, draw 10 units (5.00 mg/mL).

What is the standard Oveporexton dose?

Clinical protocols for Oveporexton typically use 0.5 mg–2 mg twice daily via subcutaneous injection. 500 mcg is a common starting dose. All dose groups demonstrated statistically significant improvements in MWT, ESS, and cataplexy. The 2 mg BID dose produced MWT improvement of 23.5 minutes (vs -1.2 min placebo) and ESS improvement of -13.8 points (vs -2.5 placebo).

How long does a vial of Oveporexton last at 500 mcg twice daily?

A 5 mg vial of Oveporexton contains roughly 10 doses at 500 mcg per injection. At twice daily dosing, that is approximately 5 days (about 1 weeks) of supply per vial. Reconstituted Oveporexton should generally be used within 28 days when refrigerated.

Where do you inject Oveporexton?

Oveporexton is typically administered subcutaneously. Common subcutaneous sites are the lower abdomen (at least an inch from the navel), the outer thigh, and the love handles. Rotate sites with each injection to reduce localized irritation and bruising.

Can I use sterile water instead of bacteriostatic water for Oveporexton?

Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Oveporexton because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.