Nomlabofusp Dosing Calculator
Pre-filled with the most-reported clinical reconstitution protocol for Nomlabofusp. See how 1 mL and 2 mL of bacteriostatic water change concentration and syringe-draw volume, then adjust the calculator below for your own vial.
Quick answer · Clinical protocol
A 30 mg vial of Nomlabofusp reconstituted with 2 mL of bacteriostatic water yields a concentration of 15.00 mg/mL. At that concentration, a 25 mg dose of Nomlabofusp equals 166.7 units on a U-100 insulin syringe (1.667 mL). Nomlabofusp is typically administered once daily.
Nomlabofusp reconstitution: 1 mL vs 2 mL bac water
Bacteriostatic water volume is flexible. Less water means higher concentration and smaller injection volumes; more water means lower concentration and easier dose precision. Both options below are valid for a 30 mg vial.
| BAC water added | Concentration | Volume per 25 mg dose | Draw on U-100 syringe (units) |
|---|---|---|---|
| 1 mL | 30.00 mg/mL | 0.833 mL | 83.3 units |
| 2 mL | 15.00 mg/mL | 1.667 mL | 166.7 units |
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Nomlabofusp reconstitution & storage
Nomlabofusp is a recombinant fusion protein supplied in a formulation for subcutaneous injection. Specific reconstitution details depend on the clinical trial formulation. As a protein therapeutic, proper cold chain handling is essential.
Store refrigerated at 2-8 degrees C. Protect from light. Do not freeze. As a recombinant protein, nomlabofusp requires cold chain storage to maintain stability and bioactivity.
Nomlabofusp dosing FAQ
How much bacteriostatic water should I add to a 30 mg vial of Nomlabofusp?
The community standard is 2 mL of bacteriostatic water for a 30 mg Nomlabofusp vial. That gives a concentration of 15.00 mg/mL, so a 25 mg dose is 166.7 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 30.00 mg/mL and halves the draw to 83.3 units. Less water = smaller injection volume but harder to measure precisely.
How many syringe units is a 25 mg dose of Nomlabofusp?
On a standard U-100 insulin syringe, a 25 mg dose of Nomlabofusp is 166.7 units when the 30 mg vial is reconstituted with 2 mL of bacteriostatic water (15.00 mg/mL). If you use 1 mL of bac water instead, draw 83.3 units (30.00 mg/mL).
What is the standard Nomlabofusp dose?
Clinical protocols for Nomlabofusp typically use 25 mg–5 mg once daily via subcutaneous injection. 25 mg is a common starting dose. Modified starting regimen implemented to mitigate anaphylaxis risk. Phase 2 studied 25 mg and 50 mg cohorts. Open-label extension uses 25 mg daily. Dose-dependent frataxin increases observed across 25-100 mg range.
How long does a vial of Nomlabofusp last at 25 mg once daily?
A 30 mg vial of Nomlabofusp contains roughly 1 doses at 25 mg per injection. At once daily dosing, that is approximately 1 days (about 0 weeks) of supply per vial. Reconstituted Nomlabofusp should generally be used within 28 days when refrigerated.
Where do you inject Nomlabofusp?
Nomlabofusp is typically injected subcutaneously. Common sites reported in the literature and by users include: Abdomen, Thigh. Rotate sites with each injection to reduce localized irritation.
Can I use sterile water instead of bacteriostatic water for Nomlabofusp?
Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Nomlabofusp because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.
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Medical Disclaimer
This website is for educational and informational purposes only. The information provided is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare professional before using any peptide or supplement.