Davunetide Dosing Calculator

Dose

2-5 mg

Frequency

1-2 times daily

Duration

4-12 weeks

Route

Intranasal

Adapted from clinical trial intranasal dosing; very few community users have attempted davunetide

Dose

30 mg twice daily via intranasal spray

Frequency

Twice daily

Duration

52 weeks

Trial failed to show efficacy. Davunetide did not differ from placebo on primary endpoints.

How much bacteriostatic water should I add to a 10 mg vial of Davunetide?

The community standard is 2 mL of bacteriostatic water for a 10 mg Davunetide vial. That gives a concentration of 5.00 mg/mL, so a 1 mg dose is 20 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 10.00 mg/mL and halves the draw to 10 units. Less water = smaller injection volume but harder to measure precisely.

How many syringe units is a 1 mg dose of Davunetide?

On a standard U-100 insulin syringe, a 1 mg dose of Davunetide is 20 units when the 10 mg vial is reconstituted with 2 mL of bacteriostatic water (5.00 mg/mL). If you use 1 mL of bac water instead, draw 10 units (10.00 mg/mL).

What is the standard Davunetide dose?

Community-reported protocols for Davunetide typically use 1 mg–5 mg once daily via Subcutaneous. 1 mg is a common starting dose. Alternative route for those who prefer injection; not the clinically studied route

How long does a vial of Davunetide last at 1 mg once daily?

A 10 mg vial of Davunetide contains roughly 10 doses at 1 mg per injection. At once daily dosing, that is approximately 10 days (about 1 weeks) of supply per vial. Reconstituted Davunetide should generally be used within 28 days when refrigerated.

Where do you inject Davunetide?

Davunetide is typically injected subcutaneous. Common sites reported in the literature and by users include: Intranasal (nasal spray delivery). Rotate sites with each injection to reduce localized irritation.

Can I use sterile water instead of bacteriostatic water for Davunetide?

Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Davunetide because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.