MET-097i Dosing Calculator
MET-097i (PF-3944): ultra-long-acting monthly GLP-1 agonist using HALO platform.
Pre-filled with the most-reported clinical reconstitution protocol for MET-097i. See how 1 mL and 2 mL of bacteriostatic water change concentration and syringe-draw volume, then adjust the calculator below for your own vial.
Quick answer · Clinical protocol
A 10 mg vial of MET-097i reconstituted with 2 mL of bacteriostatic water yields a concentration of 5.00 mg/mL. At that concentration, a 9.6 mg dose of MET-097i equals 192 units on a U-100 insulin syringe (1.920 mL). MET-097i is typically administered once daily.
MET-097i reconstitution: 1 mL vs 2 mL bac water
Bacteriostatic water volume is flexible. Less water means higher concentration and smaller injection volumes; more water means lower concentration and easier dose precision. Both options below are valid for a 10 mg vial.
| BAC water added | Concentration | Volume per 9.6 mg dose | Draw on U-100 syringe (units) |
|---|---|---|---|
| 1 mL | 10.00 mg/mL | 0.960 mL | 96 units |
| 2 mL | 5.00 mg/mL | 1.920 mL | 192 units |
Calculate your MET-097i dose
Alternative MET-097i protocols
Beyond the default above, MET-097i is also reported in the following protocols. Use these as starting points and recalculate with the tool above.
Weight Management (Direct Monthly Dosing - Modeled)
Clinical- Dose
- 9.6 mg once monthly subcutaneous injection (from PK modeling).
- Frequency
- Once monthly subcutaneous injection
- Duration
- Projected from modeling data
Direct monthly dosing protocol derived from pharmacokinetic modeling. Clinical validation in Phase 3 trials pending.
MET-097i reconstitution & storage
Reconstitution details not publicly disclosed. MET-097i is administered as a once-monthly subcutaneous injection.
Storage conditions not publicly disclosed. Refrigerated storage (2-8 degrees C) is expected for the peptide-oligomer conjugate.
MET-097i dosing FAQ
How much bacteriostatic water should I add to a 10 mg vial of MET-097i?
The community standard is 2 mL of bacteriostatic water for a 10 mg MET-097i vial. That gives a concentration of 5.00 mg/mL, so a 9.6 mg dose is 192 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 10.00 mg/mL and halves the draw to 96 units. Less water = smaller injection volume but harder to measure precisely.
How many syringe units is a 9.6 mg dose of MET-097i?
On a standard U-100 insulin syringe, a 9.6 mg dose of MET-097i is 192 units when the 10 mg vial is reconstituted with 2 mL of bacteriostatic water (5.00 mg/mL). If you use 1 mL of bac water instead, draw 96 units (10.00 mg/mL).
What is the standard MET-097i dose?
Clinical protocols for MET-097i typically use 9.6 mg once daily via subcutaneous injection. 9.6 mg is a common starting dose. The weekly-to-monthly transition achieved 12.3% weight loss at 28 weeks. Pharmacokinetic modeling suggests 9.6 mg monthly could achieve approximately 16% weight loss with continued treatment.
How long does a vial of MET-097i last at 9.6 mg once daily?
A 10 mg vial of MET-097i contains roughly 1 doses at 9.6 mg per injection. At once daily dosing, that is approximately 1 days (about 0 weeks) of supply per vial. Reconstituted MET-097i should generally be used within 28 days when refrigerated.
Where do you inject MET-097i?
MET-097i is typically injected subcutaneously. Common sites reported in the literature and by users include: Abdomen, Thigh, Upper arm. Rotate sites with each injection to reduce localized irritation.
Can I use sterile water instead of bacteriostatic water for MET-097i?
Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like MET-097i because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.
More on MET-097i
Medical Disclaimer
This website is for educational and informational purposes only. The information provided is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare professional before using any peptide or supplement.