HMG Dosing Calculator
HMG: Human menopausal gonadotropin for fertility treatment.
Pre-filled with the most-reported community reconstitution protocol for HMG. See how 1 mL and 2 mL of bacteriostatic water change concentration and syringe-draw volume, then adjust the calculator below for your own vial.
Quick answer · Community-reported standard
A 5,000 IU vial of HMG reconstituted with 2 mL of bacteriostatic water yields a concentration of 2,500 IU/mL. At that concentration, a 75 IU dose of HMG equals 3 units on a U-100 insulin syringe (0.030 mL). HMG is typically administered every other day via intramuscular.
HMG reconstitution: 1 mL vs 2 mL bac water
Bacteriostatic water volume is flexible. Less water means higher concentration and smaller injection volumes; more water means lower concentration and easier dose precision. Both options below are valid for a 5,000 IU vial.
| BAC water added | Concentration | Volume per 75 IU dose | Draw on U-100 syringe (units) |
|---|---|---|---|
| 1 mL | 5,000 IU/mL | 0.015 mL | 1.5 units |
| 2 mL | 2,500 IU/mL | 0.030 mL | 3 units |
Calculate your HMG dose
Alternative HMG protocols
Beyond the default above, HMG is also reported in the following protocols. Use these as starting points and recalculate with the tool above.
PCT FSH Support Protocol
Community- Dose
- 75 IU
- Frequency
- Every other day for 1-2 weeks
- Duration
- 1-2 weeks (alongside HCG)
- Route
- Intramuscular
Short-term PCT use to provide FSH stimulation alongside HCG for LH stimulation
Combined HCG + HMG Fertility Protocol
Community- Dose
- 75-150 IU HMG + 1500-2500 IU HCG
- Frequency
- HMG every other day, HCG 2-3x weekly
- Duration
- 3-12 months
- Route
- Intramuscular
Combined protocol for severe hypogonadal infertility; adds FSH component when LH stimulation alone insufficient
Controlled ovarian stimulation for IVF
Clinical- Dose
- 75-450 IU daily
- Frequency
- Daily subcutaneous or intramuscular injection
- Duration
- 7-20 days per stimulation cycle
Starting dose typically 75-150 IU daily; dose adjusted every 2-3 days based on ultrasound and estradiol monitoring; maximum 450 IU daily
Ovulation induction in anovulatory women
Clinical- Dose
- 75-150 IU daily
- Frequency
- Daily subcutaneous injection
- Duration
- 7-14 days until follicular maturity
Start at 75 IU; increase by no more than 37.5-75 IU per step; followed by HCG trigger when dominant follicle reaches 17-18 mm
Male hypogonadotropic hypogonadism (spermatogenesis induction)
Clinical- Dose
- 75-150 IU per injection
- Frequency
- 2-3 times per week
- Duration
- 3-6 months minimum; often 12-18 months
Combined with HCG 1500-5000 IU 2-3 times weekly; spermatogenesis rates ~76% with combined therapy
HMG reconstitution & storage
Reconstitute lyophilized powder with provided diluent (typically 1 mL sterile sodium chloride solution). Gently swirl to dissolve; do not shake.
Store unreconstituted vials at room temperature (20-25°C) or refrigerated (2-8°C). After reconstitution, use immediately or store refrigerated and use within 28 days depending on product. Protect from light.
HMG dosing FAQ
How much bacteriostatic water should I add to a 5,000 IU vial of HMG?
The community standard is 2 mL of bacteriostatic water for a 5,000 IU HMG vial. That gives a concentration of 2,500 IU/mL, so a 75 IU dose is 3 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 5,000 IU/mL and halves the draw to 1.5 units. Less water = smaller injection volume but harder to measure precisely.
How many syringe units is a 75 IU dose of HMG?
On a standard U-100 insulin syringe, a 75 IU dose of HMG is 3 units when the 5,000 IU vial is reconstituted with 2 mL of bacteriostatic water (2,500 IU/mL). If you use 1 mL of bac water instead, draw 1.5 units (5,000 IU/mL).
What is the standard HMG dose?
Community-reported protocols for HMG typically use 75–150 IU every other day via Intramuscular. 75 IU is a common starting dose. Standard fertility protocol; usually added when HCG alone has not restored spermatogenesis
How long does a vial of HMG last at 75 IU every other day?
A 5,000 IU vial of HMG contains roughly 66 doses at 75 IU per injection. At every other day dosing, that is approximately 132 days (about 19 weeks) of supply per vial. Reconstituted HMG should generally be used within 28 days when refrigerated.
Where do you inject HMG?
HMG is typically injected intramuscular. Common sites reported in the literature and by users include: Subcutaneous abdomen, Subcutaneous thigh, Intramuscular upper outer quadrant of gluteus. Rotate sites with each injection to reduce localized irritation.
Can I use sterile water instead of bacteriostatic water for HMG?
Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like HMG because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.
More on HMG
Medical Disclaimer
This website is for educational and informational purposes only. The information provided is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare professional before using any peptide or supplement.