Kisspeptin Dosing Calculator

Dose

100 mcg

Frequency

Once daily

Duration

4-8 weeks

Route

Subcutaneous

Lower dose daily approach for gradual HPG axis stimulation; some users report improved libido

Dose

50-100 mcg

Frequency

Multiple times daily (mimicking natural pulsatile release)

Duration

2-4 weeks

Route

Subcutaneous

Experimental approach attempting to mimic natural kisspeptin pulsatility; impractical for most users

Dose

9.6 nmol/kg subcutaneous (single injection)

Frequency

Single dose

Duration

One-time administration at trigger timing

Dose identified as optimal by Abbara et al. dose-optimization studies. Kisspeptin-54 administered as a single SC injection approximately 36 hours before planned oocyte retrieval.

Dose

1 nmol/kg intravenous bolus

Frequency

Single dose

Duration

One-time administration with serial LH sampling

Used to assess functional integrity of the HPG axis. LH response measured at baseline and at intervals post-injection (typically 30, 60, 120 minutes). Robust LH rise indicates intact hypothalamic-pituitary axis.

How much bacteriostatic water should I add to a 5 mg vial of Kisspeptin?

The community standard is 1 mL of bacteriostatic water for a 5 mg Kisspeptin vial. That gives a concentration of 2.50 mg/mL, so a 100 mcg dose is 4 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 5.00 mg/mL and halves the draw to 2 units. Less water = smaller injection volume but harder to measure precisely.

How many syringe units is a 100 mcg dose of Kisspeptin?

On a standard U-100 insulin syringe, a 100 mcg dose of Kisspeptin is 4 units when the 5 mg vial is reconstituted with 1 mL of bacteriostatic water (2.50 mg/mL). If you use 1 mL of bac water instead, draw 2 units (5.00 mg/mL).

What is the standard Kisspeptin dose?

Community-reported protocols for Kisspeptin typically use 100 mcg–200 mcg every other day via Subcutaneous. 100 mcg is a common starting dose. Used for LH and FSH stimulation; doses derived from clinical research showing peak LH response at approximately 1 mcg/kg

How long does a vial of Kisspeptin last at 100 mcg every other day?

A 5 mg vial of Kisspeptin contains roughly 50 doses at 100 mcg per injection. At every other day dosing, that is approximately 100 days (about 14 weeks) of supply per vial. Reconstituted Kisspeptin should generally be used within 28 days when refrigerated.

Where do you inject Kisspeptin?

Kisspeptin is typically injected subcutaneous. Common sites reported in the literature and by users include: Subcutaneous abdomen (IVF trigger protocol), Intravenous antecubital vein (diagnostic bolus). Rotate sites with each injection to reduce localized irritation.

Can I use sterile water instead of bacteriostatic water for Kisspeptin?

Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Kisspeptin because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.