Eloralintide Dosing Calculator

Dose

Stepwise escalation from 3 mg to 6 mg to 9 mg, or from 6 mg to 9 mg, over the 48-week treatment period.

Frequency

Once weekly subcutaneous injection

Duration

48 weeks (Phase 2 trial duration)

Dose escalation regimens reduced the incidence of GI adverse events compared with starting at higher fixed doses. The 6-to-9 mg arm achieved 15.8% weight loss with improved tolerability.

How much bacteriostatic water should I add to a 5 mg vial of Eloralintide?

The community standard is 2 mL of bacteriostatic water for a 5 mg Eloralintide vial. That gives a concentration of 2.50 mg/mL, so a 1 mg dose is 40 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 5.00 mg/mL and halves the draw to 20 units. Less water = smaller injection volume but harder to measure precisely.

How many syringe units is a 1 mg dose of Eloralintide?

On a standard U-100 insulin syringe, a 1 mg dose of Eloralintide is 40 units when the 5 mg vial is reconstituted with 2 mL of bacteriostatic water (2.50 mg/mL). If you use 1 mL of bac water instead, draw 20 units (5.00 mg/mL).

What is the standard Eloralintide dose?

Clinical protocols for Eloralintide typically use 1 mg–3 mg once weekly via subcutaneous injection. 1 mg is a common starting dose. Higher doses produced greater weight loss but with increased incidence of nausea and fatigue. The 9 mg dose achieved 20.1% weight loss but had nausea rates of approximately 64%.

How long does a vial of Eloralintide last at 1 mg once weekly?

A 5 mg vial of Eloralintide contains roughly 5 doses at 1 mg per injection. At once weekly dosing, that is approximately 35 days (about 5 weeks) of supply per vial. Reconstituted Eloralintide should generally be used within 28 days when refrigerated.

Where do you inject Eloralintide?

Eloralintide is typically injected subcutaneously. Common sites reported in the literature and by users include: Abdomen, Thigh, Upper arm. Rotate sites with each injection to reduce localized irritation.

Can I use sterile water instead of bacteriostatic water for Eloralintide?

Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Eloralintide because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.