Ecnoglutide Dosing Calculator

Dose

0.4 mg, 0.8 mg, or 1.2 mg once weekly subcutaneous injection for 20 weeks.

Frequency

Once weekly subcutaneous injection

Duration

20 weeks (Phase 2 trial duration)

HbA1c reductions of -1.81% (0.4 mg), -1.90% (0.8 mg), and -2.39% (1.2 mg) versus -0.55% for placebo at 20 weeks.

Dose

0.6 mg or 1.2 mg once weekly subcutaneous injection for 24 weeks.

Frequency

Once weekly subcutaneous injection

Duration

24 weeks (Phase 3 trial duration)

Phase 3 trial at 33 sites in China with 211 participants. HbA1c reductions were comparable to dual GLP-1/GIP analogs such as tirzepatide.

How much bacteriostatic water should I add to a 5 mg vial of Ecnoglutide?

The community standard is 2 mL of bacteriostatic water for a 5 mg Ecnoglutide vial. That gives a concentration of 2.50 mg/mL, so a 1.2 mg dose is 48 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 5.00 mg/mL and halves the draw to 24 units. Less water = smaller injection volume but harder to measure precisely.

How many syringe units is a 1.2 mg dose of Ecnoglutide?

On a standard U-100 insulin syringe, a 1.2 mg dose of Ecnoglutide is 48 units when the 5 mg vial is reconstituted with 2 mL of bacteriostatic water (2.50 mg/mL). If you use 1 mL of bac water instead, draw 24 units (5.00 mg/mL).

What is the standard Ecnoglutide dose?

Clinical protocols for Ecnoglutide typically use 1.2 mg–1.8 mg once weekly via subcutaneous injection. 1.2 mg is a common starting dose. The SLIMMER Phase 3 trial enrolled 664 participants randomized to ecnoglutide 1.2 mg, 1.8 mg, or 2.4 mg or placebo. Mean weight loss was 15.4% at 48 weeks with the highest dose. 92.8% achieved at least 5% weight loss.

How long does a vial of Ecnoglutide last at 1.2 mg once weekly?

A 5 mg vial of Ecnoglutide contains roughly 4 doses at 1.2 mg per injection. At once weekly dosing, that is approximately 28 days (about 4 weeks) of supply per vial. Reconstituted Ecnoglutide should generally be used within 28 days when refrigerated.

Where do you inject Ecnoglutide?

Ecnoglutide is typically injected subcutaneously. Common sites reported in the literature and by users include: Abdomen, Thigh. Rotate sites with each injection to reduce localized irritation.

Can I use sterile water instead of bacteriostatic water for Ecnoglutide?

Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Ecnoglutide because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.