Brimapitide Dosing Calculator

Dose

Single intratympanic injection of 0.4 mg/mL or 0.8 mg/mL brimapitide in hyaluronic acid gel.

Frequency

Single dose

Duration

Single administration within 72 hours of hearing loss onset. Follow-up assessments at days 3, 7, 28, and 91.

Development discontinued. The 0.4 mg/mL dose showed the most promising results in the profound hearing loss subgroup.

How much bacteriostatic water should I add to a 2 mg vial of Brimapitide?

The community standard is 2 mL of bacteriostatic water for a 2 mg Brimapitide vial. That gives a concentration of 1.00 mg/mL, so a 400 mcg dose is 40 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 2.00 mg/mL and halves the draw to 20 units. Less water = smaller injection volume but harder to measure precisely.

How many syringe units is a 400 mcg dose of Brimapitide?

On a standard U-100 insulin syringe, a 400 mcg dose of Brimapitide is 40 units when the 2 mg vial is reconstituted with 2 mL of bacteriostatic water (1.00 mg/mL). If you use 1 mL of bac water instead, draw 20 units (2.00 mg/mL).

What is the standard Brimapitide dose?

Community-reported protocols for Brimapitide typically use 0.4 mg–0.8 mg once daily via Intratympanic. 400 mcg is a common starting dose. Based on clinical trial dosing for sudden hearing loss; requires medical administration; no self-use protocols exist

How long does a vial of Brimapitide last at 400 mcg once daily?

A 2 mg vial of Brimapitide contains roughly 5 doses at 400 mcg per injection. At once daily dosing, that is approximately 5 days (about 1 weeks) of supply per vial. Reconstituted Brimapitide should generally be used within 28 days when refrigerated.

Where do you inject Brimapitide?

Brimapitide is typically injected intratympanic. Common sites reported in the literature and by users include: Intratympanic injection into the middle ear space. The gel was injected through the tympanic membrane under local anesthesia, where it remained in contact with the round window membrane to allow drug diffusion into the inner ear. This is a specialized ENT procedure.. Rotate sites with each injection to reduce localized irritation.

Can I use sterile water instead of bacteriostatic water for Brimapitide?

Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Brimapitide because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.