Neuropeptide Y: Dosing Protocols
Dosing guidelines, reconstitution, and administration information
๐TL;DR
- โข1 dosing protocols documented
- โขReconstitution instructions included
- โขStorage: Store lyophilized NPY at -20 degrees C, protected from light and moisture. Reconstituted solutions should be used promptly or stored refrigerated at 2-8 degrees C for short-term use.
Protocol Quick-Reference
PTSD and depression research
Dosing
Amount
6.8 mg
Frequency
Single dose
Duration
Single administration
Administration
Route
IntranasalTiming
Delivered via nasal atomizer device; intranasal route bypasses blood-brain barrier for direct CNS delivery
Cycle
Duration
Single dose
Repeatable
Yes
โ๏ธ Suggested Bloodwork (2 tests)
CBC with differential
When: Baseline
Why: Baseline blood cell counts
CMP (Comprehensive Metabolic Panel)
When: Baseline
Why: Baseline metabolic panel
๐ก Key Considerations
- โNot approved for therapeutic use: all data from early-phase clinical trials
- โNPY has complex effects on appetite, cardiovascular function, and stress response; systemic administration may have unintended effects
- โIntranasal delivery is required for CNS effects as NPY does not efficiently cross the blood-brain barrier systemically
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| Purpose | Dose | Frequency | Duration | Notes |
|---|---|---|---|---|
| Intranasal NPY for Major Depression (Sayed et al., 2020) | 6.8 mg intranasal insufflation | Single dose | Single administration | Randomized controlled trial in MDD patients on stable antidepressants. Effects assessed up to 48 hours post-dose. Preliminary antidepressant effects observed. |
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๐Reconstitution Instructions
Clinical trial formulations used NPY dissolved in saline for intranasal insufflation via atomizer device. Research-grade NPY should be reconstituted in sterile saline or PBS.
Recommended Injection Sites
- โIntranasal (clinical trials)
- โIntracerebroventricular (animal research)
- โIntravenous (research)
๐งStorage Requirements
Store lyophilized NPY at -20 degrees C, protected from light and moisture. Reconstituted solutions should be used promptly or stored refrigerated at 2-8 degrees C for short-term use.
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Before You Begin
Review safety warnings and contraindications before starting any protocol.
Important Disclaimer#
Neuropeptide Y is not approved for therapeutic use in any country. All dosing information is derived from early-phase clinical trials and preclinical research. NPY is an endogenous neuropeptide with complex effects on appetite, cardiovascular function, and stress response.
Clinical Trial Dosing#
Intranasal NPY for Depression (Phase 1)#
Sayed et al. (2020) conducted a randomized controlled trial in 30 patients with major depressive disorder who were on stable antidepressant medication. Patients received a single intranasal dose of 6.8 mg NPY or placebo via nasal insufflation. Effects were assessed at baseline, +1 hour, +5 hours, +24 hours, and +48 hours after administration.
Intranasal Delivery Rationale#
Intranasal administration bypasses the blood-brain barrier via olfactory and trigeminal nerve pathways, allowing direct CNS delivery. NPY has poor BBB penetration when administered systemically, making intranasal delivery essential for achieving therapeutic brain concentrations.
Route of Administration#
Clinical trials have exclusively used intranasal delivery for CNS applications. Preclinical studies have used intracerebroventricular (ICV) injection for direct brain delivery in animal models.
Reconstitution Instructions#
Clinical trial formulations dissolved NPY in sterile saline for delivery via nasal atomizer device. Research-grade lyophilized NPY should be reconstituted in sterile water or PBS.
Storage Guidelines#
Store lyophilized NPY at -20 degrees C. Reconstituted solutions should be used promptly due to potential degradation by endogenous peptidases.
Dosing Context#
Neuropeptide Y belongs to the Neuropeptide category of research peptides. Dosing protocols for Neuropeptide Y are derived from available clinical trial data. These protocols are provided for research reference only and do not constitute medical advice. Actual dosing decisions should be made by qualified healthcare providers based on individual patient factors.
Research Protocols#
The following dosing protocols have been documented in clinical research for Neuropeptide Y:
Intranasal NPY for Major Depression (Sayed et al., 2020)#
Dose: 6.8 mg intranasal insufflation
Frequency: Single dose
Duration: Single administration
Randomized controlled trial in MDD patients on stable antidepressants. Effects assessed up to 48 hours post-dose. Preliminary antidepressant effects observed.
Reconstitution and Preparation#
Clinical trial formulations used NPY dissolved in saline for intranasal insufflation via atomizer device. Research-grade NPY should be reconstituted in sterile saline or PBS.
Injection Sites#
Recommended injection sites for Neuropeptide Y include:
- Intranasal (clinical trials)
- Intracerebroventricular (animal research)
- Intravenous (research)
Site rotation is recommended to minimize local tissue reactions and ensure consistent absorption.
Storage Requirements#
Store lyophilized NPY at -20 degrees C, protected from light and moisture. Reconstituted solutions should be used promptly or stored refrigerated at 2-8 degrees C for short-term use.
Related Reading#
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Medical Disclaimer
This website is for educational and informational purposes only. The information provided is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare professional before using any peptide or supplement.