Tesofensine Dosing Calculator
Tesofensine is a small-molecule SNDRI (not a peptide) in Phase 3 for obesity.
Pre-filled with the most-reported clinical reconstitution protocol for Tesofensine. See how 1 mL and 2 mL of bacteriostatic water change concentration and syringe-draw volume, then adjust the calculator below for your own vial.
Quick answer · Clinical protocol
A 5 mg vial of Tesofensine reconstituted with 2 mL of bacteriostatic water yields a concentration of 2.50 mg/mL. At that concentration, a 250 mcg dose of Tesofensine equals 10 units on a U-100 insulin syringe (0.100 mL). Tesofensine is typically administered once daily.
Tesofensine reconstitution: 1 mL vs 2 mL bac water
Bacteriostatic water volume is flexible. Less water means higher concentration and smaller injection volumes; more water means lower concentration and easier dose precision. Both options below are valid for a 5 mg vial.
| BAC water added | Concentration | Volume per 250 mcg dose | Draw on U-100 syringe (units) |
|---|---|---|---|
| 1 mL | 5.00 mg/mL | 0.050 mL | 5 units |
| 2 mL | 2.50 mg/mL | 0.100 mL | 10 units |
Calculate your Tesofensine dose
Alternative Tesofensine protocols
Beyond the default above, Tesofensine is also reported in the following protocols. Use these as starting points and recalculate with the tool above.
Phase 2 obesity dose (Astrup 2008): mid
Clinical- Dose
- 0.5 mg
- Frequency
- Once daily, oral
- Duration
- 24 weeks
Approximately 9.2% placebo-subtracted weight loss at 24 weeks; intermediate side-effect burden. PMID 18950853.
Phase 2 obesity dose (Astrup 2008): high
Clinical- Dose
- 1.0 mg
- Frequency
- Once daily, oral
- Duration
- 24 weeks
Approximately 10.6% placebo-subtracted, approximately 12.8% total body weight loss at 24 weeks; highest weight loss but also highest rates of dry mouth, insomnia, and heart-rate increase. PMID 18950853.
Tesofensine reconstitution & storage
Room temperature, dry, dark; protect from heat and humidity (standard for oral small-molecule tablets / capsules in clinical use).
Tesofensine dosing FAQ
How much bacteriostatic water should I add to a 5 mg vial of Tesofensine?
The community standard is 2 mL of bacteriostatic water for a 5 mg Tesofensine vial. That gives a concentration of 2.50 mg/mL, so a 250 mcg dose is 10 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 5.00 mg/mL and halves the draw to 5 units. Less water = smaller injection volume but harder to measure precisely.
How many syringe units is a 250 mcg dose of Tesofensine?
On a standard U-100 insulin syringe, a 250 mcg dose of Tesofensine is 10 units when the 5 mg vial is reconstituted with 2 mL of bacteriostatic water (2.50 mg/mL). If you use 1 mL of bac water instead, draw 5 units (5.00 mg/mL).
What is the standard Tesofensine dose?
Clinical protocols for Tesofensine typically use 0.25 mg once daily via subcutaneous injection. 250 mcg is a common starting dose. Approximately 4.5% placebo-subtracted weight loss at 24 weeks; lowest side-effect burden of the three doses studied. PMID 18950853.
How long does a vial of Tesofensine last at 250 mcg once daily?
A 5 mg vial of Tesofensine contains roughly 20 doses at 250 mcg per injection. At once daily dosing, that is approximately 20 days (about 3 weeks) of supply per vial. Reconstituted Tesofensine should generally be used within 28 days when refrigerated.
Where do you inject Tesofensine?
Tesofensine is typically administered subcutaneously. Common subcutaneous sites are the lower abdomen (at least an inch from the navel), the outer thigh, and the love handles. Rotate sites with each injection to reduce localized irritation and bruising.
Can I use sterile water instead of bacteriostatic water for Tesofensine?
Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Tesofensine because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.
More on Tesofensine
Medical Disclaimer
This website is for educational and informational purposes only. The information provided is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare professional before using any peptide or supplement.