IO102-IO103 Dosing Calculator
IO102-IO103 (Cylembio): dual IDO/PD-L1 peptide cancer vaccine.
Pre-filled with the most-reported clinical reconstitution protocol for IO102-IO103. See how 1 mL and 2 mL of bacteriostatic water change concentration and syringe-draw volume, then adjust the calculator below for your own vial.
Quick answer · Clinical protocol
A 15 mg vial of IO102-IO103 reconstituted with 2 mL of bacteriostatic water yields a concentration of 7.50 mg/mL. At that concentration, a 102 mg dose of IO102-IO103 equals 1360 units on a U-100 insulin syringe (13.600 mL). IO102-IO103 is typically administered once daily.
IO102-IO103 reconstitution: 1 mL vs 2 mL bac water
Bacteriostatic water volume is flexible. Less water means higher concentration and smaller injection volumes; more water means lower concentration and easier dose precision. Both options below are valid for a 15 mg vial.
| BAC water added | Concentration | Volume per 102 mg dose | Draw on U-100 syringe (units) |
|---|---|---|---|
| 1 mL | 15.00 mg/mL | 6.800 mL | 680 units |
| 2 mL | 7.50 mg/mL | 13.600 mL | 1360 units |
Calculate your IO102-IO103 dose
IO102-IO103 reconstitution & storage
IO102-IO103 is an investigational product administered only within clinical trials. The peptides are formulated with Montanide ISA-51 adjuvant prior to subcutaneous injection. Preparation is performed by trained clinical trial staff according to the study protocol.
Storage conditions per clinical trial protocol. Peptide vaccines typically require refrigerated storage at 2-8 degrees C. Montanide ISA-51 adjuvant has separate storage requirements.
IO102-IO103 dosing FAQ
How much bacteriostatic water should I add to a 15 mg vial of IO102-IO103?
The community standard is 2 mL of bacteriostatic water for a 15 mg IO102-IO103 vial. That gives a concentration of 7.50 mg/mL, so a 102 mg dose is 1360 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 15.00 mg/mL and halves the draw to 680 units. Less water = smaller injection volume but harder to measure precisely.
How many syringe units is a 102 mg dose of IO102-IO103?
On a standard U-100 insulin syringe, a 102 mg dose of IO102-IO103 is 1360 units when the 15 mg vial is reconstituted with 2 mL of bacteriostatic water (7.50 mg/mL). If you use 1 mL of bac water instead, draw 680 units (15.00 mg/mL).
What is the standard IO102-IO103 dose?
Clinical protocols for IO102-IO103 typically use 102 mgâ103 mg once daily via subcutaneous injection. 102 mg is a common starting dose. IO102-IO103 is administered as a combination with checkpoint inhibitors and is not used as monotherapy. The vaccine requires Montanide ISA-51 (incomplete Freund's adjuvant) as an immunological adjuvant to enhance the T cell response. Exact dosing is per clinical trial protocol.
Where do you inject IO102-IO103?
IO102-IO103 is typically injected subcutaneously. Common sites reported in the literature and by users include: Subcutaneous (clinical trial protocol-specified sites). Rotate sites with each injection to reduce localized irritation.
Can I use sterile water instead of bacteriostatic water for IO102-IO103?
Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like IO102-IO103 because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.
More on IO102-IO103
IO102-IO103 overview
Mechanism of action, primary uses, and research summary
IO102-IO103 dosing protocols
Full clinical and research-based dosing reference
IO102-IO103 community protocols
Real-world usage patterns from peptide communities
IO102-IO103 side effects
Reported adverse effects and safety considerations
Medical Disclaimer
This website is for educational and informational purposes only. The information provided is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare professional before using any peptide or supplement.