Setmelanotide (IMCIVREE) Dosing Calculator

Dose

Weight-based titration to maintenance dose

Frequency

Once daily

Duration

Ongoing

Route

Subcutaneous injection

FDA approval expanded in 2022 to include BBS; available through Rhythm InTune support program

Dose

Frequency

Once daily

Administer once daily at the start of the day. Inject into the abdomen. Rotate injection sites with each injection.

Dose

Frequency

Once daily

Pediatric dose titration is more gradual (1 mg increments every 2 weeks). Same injection site and rotation guidance as adults.

How much bacteriostatic water should I add to a 10 mg vial of Setmelanotide (IMCIVREE)?

The community standard is 2 mL of bacteriostatic water for a 10 mg Setmelanotide (IMCIVREE) vial. That gives a concentration of 5.00 mg/mL, so a 1 mg dose is 20 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 10.00 mg/mL and halves the draw to 10 units. Less water = smaller injection volume but harder to measure precisely.

How many syringe units is a 1 mg dose of Setmelanotide (IMCIVREE)?

On a standard U-100 insulin syringe, a 1 mg dose of Setmelanotide (IMCIVREE) is 20 units when the 10 mg vial is reconstituted with 2 mL of bacteriostatic water (5.00 mg/mL). If you use 1 mL of bac water instead, draw 10 units (10.00 mg/mL).

What is the standard Setmelanotide (IMCIVREE) dose?

Community-reported protocols for Setmelanotide (IMCIVREE) typically use 1 mg–3 mg once daily via Subcutaneous injection. 1 mg is a common starting dose. FDA-approved for patients aged 6+ with obesity due to POMC, PCSK1, or LEPR deficiency confirmed by genetic testing

How long does a vial of Setmelanotide (IMCIVREE) last at 1 mg once daily?

A 10 mg vial of Setmelanotide (IMCIVREE) contains roughly 10 doses at 1 mg per injection. At once daily dosing, that is approximately 10 days (about 1 weeks) of supply per vial. Reconstituted Setmelanotide (IMCIVREE) should generally be used within 28 days when refrigerated.

Where do you inject Setmelanotide (IMCIVREE)?

Setmelanotide (IMCIVREE) is typically injected subcutaneous injection. Common sites reported in the literature and by users include: Abdomen (preferred). Rotate sites with each injection to reduce localized irritation.

Can I use sterile water instead of bacteriostatic water for Setmelanotide (IMCIVREE)?

Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Setmelanotide (IMCIVREE) because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.