Bimagrumab Dosing Calculator

Dose

10 mg/kg

Frequency

Every 4 weeks

Duration

48 weeks

Route

Intravenous infusion

Demonstrated 20.5% fat loss with 3.6% lean mass gain in type 2 diabetes and obesity

Dose

10 mg/kg IV every 4 weeks for 48 weeks. In the Heymsfield et al. (JAMA Network Open 2021) trial, this dose produced 20.5% fat mass loss and 3.6% lean mass gain in adults with T2D and obesity (BMI 28-40).

Frequency

Every 4 weeks (Q4W) intravenous infusion

Duration

48 weeks in the Phase 2 RCT

Both groups received diet and exercise counseling. This is the only dose tested in the obesity RCT. Optimal dose for body composition effects not fully established.

Dose

Bimagrumab IV infusion at weeks 4, 16, 28, and 40 in combination with semaglutide SC weekly. The combination achieved 22.1% total weight loss with 92.8% from fat mass and preserved 67% more lean mass than semaglutide alone.

Frequency

IV infusion approximately every 12 weeks (4 total infusions)

Duration

48 weeks

Phase 2b trial with 507 participants. Semaglutide was administered as standard weekly subcutaneous injection. Specific bimagrumab dose (mg/kg) from BELIEVE should be confirmed from primary publication.

Dose

30 mg/kg IV in community-dwelling older adults (65+) with sarcopenia. Increased muscle mass and strength over 16 weeks.

Frequency

Single dose or repeated IV infusions

Duration

16 weeks in the proof-of-concept study

Higher dose (30 mg/kg) used in sarcopenia vs obesity (10 mg/kg). Small proof-of-concept (n=40). Dose-response relationship across indications not fully characterized.

Dose

1, 3, or 10 mg/kg IV every 4 weeks for 52 weeks. The primary endpoint (6-minute walk distance) was not met at any dose. Dose-response analysis showed no clear dose-response relationship for functional outcomes.

Frequency

Every 4 weeks (Q4W) intravenous infusion

Duration

52 weeks (core study)

Largest IBM trial (n=251) at 38 sites. Failed primary endpoint at all dose levels. 10 mg/kg showed some patient-reported outcome preservation.

How much bacteriostatic water should I add to a 10 mg vial of Bimagrumab?

The community standard is 2 mL of bacteriostatic water for a 10 mg Bimagrumab vial. That gives a concentration of 5.00 mg/mL, so a 10 mg dose is 200 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 10.00 mg/mL and halves the draw to 100 units. Less water = smaller injection volume but harder to measure precisely.

How many syringe units is a 10 mg dose of Bimagrumab?

On a standard U-100 insulin syringe, a 10 mg dose of Bimagrumab is 200 units when the 10 mg vial is reconstituted with 2 mL of bacteriostatic water (5.00 mg/mL). If you use 1 mL of bac water instead, draw 100 units (10.00 mg/mL).

What is the standard Bimagrumab dose?

Community-reported protocols for Bimagrumab typically use 10 mg once daily via Intravenous infusion. 10 mg is a common starting dose. Clinical trial protocol combined with semaglutide 2.4 mg weekly; not yet commercially available

How long does a vial of Bimagrumab last at 10 mg once daily?

A 10 mg vial of Bimagrumab contains roughly 1 doses at 10 mg per injection. At once daily dosing, that is approximately 1 days (about 0 weeks) of supply per vial. Reconstituted Bimagrumab should generally be used within 28 days when refrigerated.

Where do you inject Bimagrumab?

Bimagrumab is typically administered intravenous infusion. Common subcutaneous sites are the lower abdomen (at least an inch from the navel), the outer thigh, and the love handles. Rotate sites with each injection to reduce localized irritation and bruising.

Can I use sterile water instead of bacteriostatic water for Bimagrumab?

Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Bimagrumab because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.