OS-01 (Peptide 14): Molecular Structure

Molecular Structure#

OS-01 (Peptide 14) is a synthetic peptide consisting of 10 amino acid residues. Its INCI (International Nomenclature of Cosmetic Ingredients) designation is Decapeptide-52, confirming its decapeptide classification.

Known Structural Features#

The exact amino acid sequence of OS-01 is proprietary to OneSkin and has not been disclosed in published literature or patent filings in sufficient detail for independent synthesis. What is known:

• Length: 10 amino acids (decapeptide)
• INCI name: Decapeptide-52
• Solubility: Water-soluble
• pH stability: Stable at skin-friendly pH levels (approximately neutral)
• Size: Small peptide relying on its compact size and amino acid composition for skin penetration

Molecular Weight and Formula#

The full molecular weight and formula have not been definitively established in published literature due to the proprietary sequence. The peptide is designed to be small enough for topical bioavailability without requiring delivery vehicles or chemical modifications.

Design Rationale#

OS-01 was identified through a screening of over 900 novel peptide candidates specifically designed to target cellular senescence. The selection criteria prioritized:

• Ability to reduce senescence markers in human dermal fibroblasts
• Low cytotoxicity at effective concentrations
• Suitability for topical formulation (water solubility, pH stability, skin penetration)
• Activity across multiple senescence induction models

Chemical Properties#

Stability#

OS-01 is reported to be stable in topical formulations at room temperature, as evidenced by the commercial product shelf life. No specific degradation studies have been published.

Target Interaction#

OS-01 modulates protein phosphatase 2A (PP2A), specifically interacting with the PPP2R1A scaffold regulatory subunit. The binding affinity and kinetic parameters for this interaction have not been publicly reported.

Comparison to Other Senotherapeutic Peptides#

Unlike FOXO4-DRI, which is a 24-amino acid D-retro-inverso peptide designed to disrupt the p53-FOXO4 interaction, OS-01 is a shorter peptide (10 vs 24 amino acids) with a distinct target (PP2A vs p53-FOXO4). The smaller size of OS-01 may contribute to its suitability for topical delivery, while FOXO4-DRI has been studied only as an injectable.