5-Amino-1MQ: Dosing Protocols
Dosing guidelines, reconstitution, and administration information
๐TL;DR
- โข2 dosing protocols documented
- โขReconstitution instructions included
- โขStorage: Store as a dry powder at -20C for long-term storage. Protect from light and moisture. Follow manufacturer specifications for specific salt forms. Commercial capsule products should be stored according to label directions.
Protocol Quick-Reference
PRECLINICAL ONLY: NNMT inhibition research compound
Dosing
Amount
No established human dose (mouse: ~34 mg/kg/day SC)
Frequency
No established human frequency
Duration
No established human duration
Administration
Route
OralSchedule
N/A (preclinical compound)
Timing
NO HUMAN DOSING DATA EXISTS. All protocols are animal-derived.
Cycle
Duration
No established protocol
Repeatable
Single cycle
๐ก Key Considerations
- โCRITICAL: No human clinical trials have been conducted
- โAll dosing information is from preclinical animal studies only
- โOral bioavailability in humans is unknown and uncharacterized
- โNot FDA-approved or regulated as a pharmaceutical
- โCommunity-reported doses lack clinical validation
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| Purpose | Dose | Frequency | Duration | Notes |
|---|---|---|---|---|
| Three subcutaneous injections daily | 11 days | ANIMAL PROTOCOL ONLY. This dose is for mice and cannot be directly extrapolated to humans. Route was subcutaneous injection, not oral. | ||
| Not fully specified in public abstract | Study-specific duration | ANIMAL PROTOCOL ONLY. Combined with exercise training in some cohorts. Specific dosing details in published methods section. |
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๐Reconstitution Instructions
5-Amino-1MQ is available as a small molecule compound, typically as the iodide or chloride salt. In research settings, it is dissolved in appropriate solvents for in vitro use or prepared for subcutaneous injection in animal studies. No standard reconstitution protocol exists for human use.
๐งStorage Requirements
Store as a dry powder at -20C for long-term storage. Protect from light and moisture. Follow manufacturer specifications for specific salt forms. Commercial capsule products should be stored according to label directions.
Community Dosing Protocols
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Before You Begin
Review safety warnings and contraindications before starting any protocol.
Important Disclaimer#
No Human Dosing Data Exists -- 5-Amino-1MQ has never been tested in human clinical trials. There are no validated human dosing protocols, no established therapeutic dose ranges, and no human pharmacokinetic data. The information below describes how the compound has been used in published animal studies only.
5-Amino-1MQ is a preclinical research compound that has not undergone the clinical development process necessary to establish safe and effective dosing in humans. Any human use is unguided by clinical evidence and carries unknown risks.
Research-Based Dosing Information#
Animal Study Protocols#
Obesity Study (2018)
The foundational study by Neelakantan et al. (PMID: 29155147) used the following protocol in mice:
- Species: C57BL/6 mice with diet-induced obesity (16 weeks high-fat diet)
- Route: Subcutaneous injection
- Dose: 20 mg/kg per injection
- Frequency: 3 injections per day
- Total daily dose: Approximately 34 mg/kg/day
- Duration: 11 days
- Group size: n=9 per cohort
Microbiome Study (2022)
Neelakantan et al. (PMID: 35013352) used 5-Amino-1MQ in combination with dietary modification in diet-induced obese mice. The NNMTi treatment was combined with switch from high-fat to low-fat diet.
Muscle Function Study (2024)
Dimet-Wiley et al. (PMID: 38969654) evaluated NNMTi in aged mice across four conditions: sedentary control, NNMTi alone, exercise alone, and NNMTi + exercise. Specific dosing details are in the published methods.
Critical Caveats About Animal Doses#
- Mouse doses cannot be directly converted to human doses using simple weight scaling. Allometric scaling, differences in metabolic rate, body surface area, and species-specific pharmacokinetics all affect translation
- The animal studies used subcutaneous injection, while many commercially available products are oral capsules. Oral bioavailability of 5-Amino-1MQ has not been characterized in published literature
- A published study on LC-MS/MS analytical methods for 5-Amino-1MQ in rat plasma (PMID: 34304009) exists, but does not establish oral bioavailability
- The HED (Human Equivalent Dose) calculator on this site can provide allometric dose conversion estimates, but these are mathematical approximations only, not clinically validated doses
Route of Administration#
In published preclinical studies, 5-Amino-1MQ has been administered by subcutaneous injection only. Despite this, the compound is commercially available in oral capsule form. This disconnect between the research evidence (injectable) and the market availability (oral) represents a significant gap -- oral bioavailability may be substantially different from injectable bioavailability, and no published study has characterized this.
Storage Guidelines#
- Powder form: Store at -20 degrees C, protected from light and moisture
- Solution: Prepare fresh for research use; stability data in solution is limited
- Commercial capsules: Follow manufacturer storage directions (typically room temperature)
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Medical Disclaimer
This website is for educational and informational purposes only. The information provided is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare professional before using any peptide or supplement.