Risuteganib Dosing Calculator

Dose

1.0 mg intravitreal injection.

Frequency

Every 12 weeks

Duration

5 intravitreal injections 12 weeks apart, with continued treatment during the follow-up safety period. Primary endpoint assessed at 52 weeks.

FDA Special Protocol Assessment agreement received for this trial design. Study ongoing.

How much bacteriostatic water should I add to a 5 mg vial of Risuteganib?

The community standard is 2 mL of bacteriostatic water for a 5 mg Risuteganib vial. That gives a concentration of 2.50 mg/mL, so a 1 mg dose is 40 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 5.00 mg/mL and halves the draw to 20 units. Less water = smaller injection volume but harder to measure precisely.

How many syringe units is a 1 mg dose of Risuteganib?

On a standard U-100 insulin syringe, a 1 mg dose of Risuteganib is 40 units when the 5 mg vial is reconstituted with 2 mL of bacteriostatic water (2.50 mg/mL). If you use 1 mL of bac water instead, draw 20 units (5.00 mg/mL).

What is the standard Risuteganib dose?

Clinical protocols for Risuteganib typically use 1 mg–2 mg once daily via subcutaneous injection. 1 mg is a common starting dose. Investigational dosing. Phase 2b/3 design uses 5 intravitreal injections 12 weeks apart with continued treatment during follow-up.

How long does a vial of Risuteganib last at 1 mg once daily?

A 5 mg vial of Risuteganib contains roughly 5 doses at 1 mg per injection. At once daily dosing, that is approximately 5 days (about 1 weeks) of supply per vial. Reconstituted Risuteganib should generally be used within 28 days when refrigerated.

Where do you inject Risuteganib?

Risuteganib is typically injected subcutaneously. Common sites reported in the literature and by users include: Intravitreal injection only. Administered into the vitreous cavity of the eye by a qualified retinal specialist under sterile conditions. This is not a subcutaneous, intramuscular, or intravenous injection.. Rotate sites with each injection to reduce localized irritation.

Can I use sterile water instead of bacteriostatic water for Risuteganib?

Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Risuteganib because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.