Motixafortide Dosing Calculator
Motixafortide (APHEXDA): FDA-approved CXCR4 antagonist peptide for stem cell mobilization in multiple myeloma.
Pre-filled with the most-reported clinical reconstitution protocol for Motixafortide. See how 1 mL and 2 mL of bacteriostatic water change concentration and syringe-draw volume, then adjust the calculator below for your own vial.
Quick answer · Clinical protocol
A 10 mg vial of Motixafortide reconstituted with 2 mL of bacteriostatic water yields a concentration of 5.00 mg/mL. At that concentration, a 1.25 mg dose of Motixafortide equals 25 units on a U-100 insulin syringe (0.250 mL). Motixafortide is typically administered once daily.
Motixafortide reconstitution: 1 mL vs 2 mL bac water
Bacteriostatic water volume is flexible. Less water means higher concentration and smaller injection volumes; more water means lower concentration and easier dose precision. Both options below are valid for a 10 mg vial.
| BAC water added | Concentration | Volume per 1.25 mg dose | Draw on U-100 syringe (units) |
|---|---|---|---|
| 1 mL | 10.00 mg/mL | 0.125 mL | 12.5 units |
| 2 mL | 5.00 mg/mL | 0.250 mL | 25 units |
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Motixafortide reconstitution & storage
Each vial is reconstituted with 2 mL of 0.45% Sodium Chloride Injection, USP at room temperature (20-25 degrees C), resulting in a concentration of 36.5 mg/mL. Up to 1.7 mL (62 mg) can be withdrawn from each reconstituted vial. Reconstituted solution should be used within 4 hours.
Store vials at 2-8 degrees C (36-46 degrees F). Protect from light. Store in original carton. Reconstituted solution may be stored at room temperature (20-25 degrees C) for up to 4 hours.
Motixafortide dosing FAQ
How much bacteriostatic water should I add to a 10 mg vial of Motixafortide?
The community standard is 2 mL of bacteriostatic water for a 10 mg Motixafortide vial. That gives a concentration of 5.00 mg/mL, so a 1.25 mg dose is 25 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 10.00 mg/mL and halves the draw to 12.5 units. Less water = smaller injection volume but harder to measure precisely.
How many syringe units is a 1.25 mg dose of Motixafortide?
On a standard U-100 insulin syringe, a 1.25 mg dose of Motixafortide is 25 units when the 10 mg vial is reconstituted with 2 mL of bacteriostatic water (5.00 mg/mL). If you use 1 mL of bac water instead, draw 12.5 units (10.00 mg/mL).
What is the standard Motixafortide dose?
Clinical protocols for Motixafortide typically use 1.25 mgâ10 mg once daily via subcutaneous injection. 1.25 mg is a common starting dose. Must be administered in a healthcare setting equipped to manage anaphylaxis. Premedication with H1 blocker, H2 blocker, leukotriene inhibitor, and acetaminophen is required.
How long does a vial of Motixafortide last at 1.25 mg once daily?
A 10 mg vial of Motixafortide contains roughly 8 doses at 1.25 mg per injection. At once daily dosing, that is approximately 8 days (about 1 weeks) of supply per vial. Reconstituted Motixafortide should generally be used within 28 days when refrigerated.
Where do you inject Motixafortide?
Motixafortide is typically injected subcutaneously. Common sites reported in the literature and by users include: Subcutaneous injection. Administered by a healthcare provider in a clinical setting equipped for anaphylaxis management.. Rotate sites with each injection to reduce localized irritation.
Can I use sterile water instead of bacteriostatic water for Motixafortide?
Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Motixafortide because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.
More on Motixafortide
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Full clinical and research-based dosing reference
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Motixafortide side effects
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Medical Disclaimer
This website is for educational and informational purposes only. The information provided is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare professional before using any peptide or supplement.