Enlicitide Decanoate Dosing Calculator
Enlicitide decanoate (MK-0616): first oral macrocyclic peptide PCSK9 inhibitor.
Pre-filled with the most-reported clinical reconstitution protocol for Enlicitide Decanoate. See how 1 mL and 2 mL of bacteriostatic water change concentration and syringe-draw volume, then adjust the calculator below for your own vial.
Quick answer · Clinical protocol
A 15 mg vial of Enlicitide Decanoate reconstituted with 2 mL of bacteriostatic water yields a concentration of 7.50 mg/mL. At that concentration, a 20 mg dose of Enlicitide Decanoate equals 266.7 units on a U-100 insulin syringe (2.667 mL). Enlicitide Decanoate is typically administered once daily.
Enlicitide Decanoate reconstitution: 1 mL vs 2 mL bac water
Bacteriostatic water volume is flexible. Less water means higher concentration and smaller injection volumes; more water means lower concentration and easier dose precision. Both options below are valid for a 15 mg vial.
| BAC water added | Concentration | Volume per 20 mg dose | Draw on U-100 syringe (units) |
|---|---|---|---|
| 1 mL | 15.00 mg/mL | 1.333 mL | 133.3 units |
| 2 mL | 7.50 mg/mL | 2.667 mL | 266.7 units |
Calculate your Enlicitide Decanoate dose
Alternative Enlicitide Decanoate protocols
Beyond the default above, Enlicitide Decanoate is also reported in the following protocols. Use these as starting points and recalculate with the tool above.
Hypercholesterolemia (Phase 2b Dose Range)
Clinical- Dose
- 6-30 mg orally once daily
- Frequency
- Once daily oral administration
- Duration
- 8 weeks evaluated in Phase 2b
Phase 2b tested 6, 12, 18, and 30 mg doses. LDL-C reductions ranged from 41.2% to 60.9%. The 20 mg dose for Phase 3 was selected to optimize the efficacy-safety balance.
Enlicitide Decanoate reconstitution & storage
No reconstitution required. Enlicitide is formulated as an oral tablet for direct administration. This is a key advantage over injectable PCSK9 inhibitors that require subcutaneous injection.
Storage conditions for enlicitide tablets have not been publicly disclosed in detail from clinical trial protocols. Standard oral tablet storage at room temperature, protected from moisture, is expected.
Enlicitide Decanoate dosing FAQ
How much bacteriostatic water should I add to a 15 mg vial of Enlicitide Decanoate?
The community standard is 2 mL of bacteriostatic water for a 15 mg Enlicitide Decanoate vial. That gives a concentration of 7.50 mg/mL, so a 20 mg dose is 266.7 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 15.00 mg/mL and halves the draw to 133.3 units. Less water = smaller injection volume but harder to measure precisely.
How many syringe units is a 20 mg dose of Enlicitide Decanoate?
On a standard U-100 insulin syringe, a 20 mg dose of Enlicitide Decanoate is 266.7 units when the 15 mg vial is reconstituted with 2 mL of bacteriostatic water (7.50 mg/mL). If you use 1 mL of bac water instead, draw 133.3 units (15.00 mg/mL).
What is the standard Enlicitide Decanoate dose?
Clinical protocols for Enlicitide Decanoate typically use 20 mg once daily via subcutaneous injection. 20 mg is a common starting dose. This dose was used in the Phase 3 CORALreef Lipids and CORALreef HeFH trials. Selected based on dose-response modeling from Phase 2b data. Administered as add-on to existing lipid-lowering therapy including statins.
Where do you inject Enlicitide Decanoate?
Enlicitide Decanoate is typically administered subcutaneously. Common subcutaneous sites are the lower abdomen (at least an inch from the navel), the outer thigh, and the love handles. Rotate sites with each injection to reduce localized irritation and bruising.
Can I use sterile water instead of bacteriostatic water for Enlicitide Decanoate?
Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Enlicitide Decanoate because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.
More on Enlicitide Decanoate
Enlicitide Decanoate overview
Mechanism of action, primary uses, and research summary
Enlicitide Decanoate dosing protocols
Full clinical and research-based dosing reference
Enlicitide Decanoate community protocols
Real-world usage patterns from peptide communities
Enlicitide Decanoate side effects
Reported adverse effects and safety considerations
Medical Disclaimer
This website is for educational and informational purposes only. The information provided is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare professional before using any peptide or supplement.