Aleniglipron Dosing Calculator

Dose

240 mg once daily (exploratory higher dose).

Frequency

Once daily oral tablet

Duration

36 weeks (exploratory study)

The exploratory 240 mg dose showed up to 15.3% placebo-adjusted weight loss at 36 weeks.

How much bacteriostatic water should I add to a 10 mg vial of Aleniglipron?

The community standard is 2 mL of bacteriostatic water for a 10 mg Aleniglipron vial. That gives a concentration of 5.00 mg/mL, so a 5 mg dose is 100 units on a U-100 insulin syringe. Adding 1 mL instead doubles the concentration to 10.00 mg/mL and halves the draw to 50 units. Less water = smaller injection volume but harder to measure precisely.

How many syringe units is a 5 mg dose of Aleniglipron?

On a standard U-100 insulin syringe, a 5 mg dose of Aleniglipron is 100 units when the 10 mg vial is reconstituted with 2 mL of bacteriostatic water (5.00 mg/mL). If you use 1 mL of bac water instead, draw 50 units (10.00 mg/mL).

What is the standard Aleniglipron dose?

Clinical protocols for Aleniglipron typically use 5 mg–4 mg once daily via subcutaneous injection. 5 mg is a common starting dose. The 120 mg dose achieved 11.3% placebo-adjusted weight loss at 36 weeks. 86% of 120 mg participants achieved 5% or more weight loss, and 70% achieved 10% or more.

How long does a vial of Aleniglipron last at 5 mg once daily?

A 10 mg vial of Aleniglipron contains roughly 2 doses at 5 mg per injection. At once daily dosing, that is approximately 2 days (about 0 weeks) of supply per vial. Reconstituted Aleniglipron should generally be used within 28 days when refrigerated.

Where do you inject Aleniglipron?

Aleniglipron is typically administered subcutaneously. Common subcutaneous sites are the lower abdomen (at least an inch from the navel), the outer thigh, and the love handles. Rotate sites with each injection to reduce localized irritation and bruising.

Can I use sterile water instead of bacteriostatic water for Aleniglipron?

Bacteriostatic water (containing 0.9% benzyl alcohol as a preservative) is strongly preferred for multi-dose vials like Aleniglipron because it inhibits microbial growth and lets a single vial be used over multiple weeks. Sterile water has no preservative and should generally be reserved for single-use preparations only.